POP1
Gene Information
- Official Symbol: POP1
- Official Name: POP1 homolog, ribonuclease P/MRP subunit
- Aliases and Previous Symbols: N/A
- Entrez ID: 10940
- UniProt: Q99575
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes the protein subunit of two different small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is a ribonuclease that localizes to the nucleus and functions in pre-RNA processing. This protein is also an autoantigen in patients suffering from connective tissue diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009].
- UniProt Summary: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 757
- Expression level (log2 read counts): 5.3
POP1 Expression in NALM6 Cells: 5.3
