POR
Gene Information
- Official Symbol: POR
- Official Name: cytochrome p450 oxidoreductase
- Aliases and Previous Symbols: N/A
- Entrez ID: 5447
- UniProt: P16435
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. [provided by RefSeq, Jul 2008].
- UniProt Summary: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. {ECO:0000255|HAMAP- Rule:MF_03212}.
Pfam Domains GO Terms
Pfam Domains
| Flavodoxin 1 |
| FAD binding 1 |
| NAD binding 1 |
GO Terms
| iron-cytochrome-c reductase activity |
| cellular organohalogen metabolic process |
| cellular organofluorine metabolic process |
| nitrate catabolic process |
| nitric oxide catabolic process |
| nitric oxide dioxygenase activity |
| regulation of growth plate cartilage chondrocyte proliferation |
| positive regulation of steroid hormone biosynthetic process |
| nitrate metabolic process |
| positive regulation of cholesterol biosynthetic process |
| NADPH-hemoprotein reductase activity |
| positive regulation of sterol biosynthetic process |
| positive regulation of cholesterol metabolic process |
| cytochrome-b5 reductase activity, acting on NAD(P)H |
| regulation of steroid hormone biosynthetic process |
| positive regulation of hormone biosynthetic process |
| cellular response to follicle-stimulating hormone stimulus |
| carnitine metabolic process |
| flavonoid metabolic process |
| positive regulation of hormone metabolic process |
| response to follicle-stimulating hormone |
| FMN binding |
| nitric oxide metabolic process |
| negative regulation of lipase activity |
| positive regulation of steroid biosynthetic process |
| amino-acid betaine metabolic process |
| cellular response to gonadotropin stimulus |
| reactive nitrogen species metabolic process |
| positive regulation of chondrocyte differentiation |
| neurotransmitter catabolic process |
| regulation of bone development |
| positive regulation of alcohol biosynthetic process |
| regulation of hormone biosynthetic process |
| positive regulation of monooxygenase activity |
| positive regulation of steroid metabolic process |
| response to gonadotropin |
| positive regulation of smoothened signaling pathway |
| positive regulation of cartilage development |
| NADP binding |
| regulation of hormone metabolic process |
| regulation of sterol biosynthetic process |
| regulation of cholesterol biosynthetic process |
| regulation of chondrocyte differentiation |
| positive regulation of oxidoreductase activity |
| regulation of monooxygenase activity |
| regulation of cholesterol metabolic process |
| flavin adenine dinucleotide binding |
| demethylation |
| regulation of cartilage development |
| regulation of alcohol biosynthetic process |
| electron transfer activity |
| fatty acid oxidation |
| regulation of smoothened signaling pathway |
| hydrolase activity |
| lipid oxidation |
| positive regulation of lipid biosynthetic process |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of steroid biosynthetic process |
| negative regulation of cysteine-type endopeptidase activity |
| neurotransmitter metabolic process |
| regulation of organ growth |
| regulation of oxidoreductase activity |
| regulation of lipase activity |
| reactive oxygen species metabolic process |
| regulation of steroid metabolic process |
| internal peptidyl-lysine acetylation |
| oxidoreductase activity |
| peptidyl-lysine acetylation |
| internal protein amino acid acetylation |
| xenobiotic metabolic process |
| positive regulation of small molecule metabolic process |
| positive regulation of lipid metabolic process |
| protein acetylation |
| drug catabolic process |
| electron transport chain |
| cellular response to xenobiotic stimulus |
| regulation of lipid biosynthetic process |
| protein acylation |
| ammonium ion metabolic process |
| cellular modified amino acid metabolic process |
| lipid modification |
| response to nutrient |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of endopeptidase activity |
| negative regulation of peptidase activity |
| regulation of animal organ morphogenesis |
| cellular response to peptide hormone stimulus |
| response to xenobiotic stimulus |
| peptidyl-lysine modification |
| fatty acid metabolic process |
| cellular response to peptide |
| regulation of developmental growth |
| enzyme binding |
| negative regulation of proteolysis |
| regulation of neurotransmitter levels |
| response to peptide hormone |
| regulation of lipid metabolic process |
| regulation of endopeptidase activity |
| generation of precursor metabolites and energy |
| regulation of small molecule metabolic process |
| cellular nitrogen compound catabolic process |
| regulation of peptidase activity |
| negative regulation of hydrolase activity |
| response to peptide |
| response to nutrient levels |
| drug metabolic process |
| monocarboxylic acid metabolic process |
| response to extracellular stimulus |
| regulation of hormone levels |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| cellular response to nitrogen compound |
| regulation of growth |
| intracellular membrane-bounded organelle |
| regulation of proteolysis |
| negative regulation of catalytic activity |
| peptidyl-amino acid modification |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| carboxylic acid metabolic process |
| response to hormone |
| endoplasmic reticulum membrane |
| cellular lipid metabolic process |
| oxidation-reduction process |
| positive regulation of cell differentiation |
| negative regulation of cell death |
| response to organonitrogen compound |
| oxoacid metabolic process |
| response to drug |
| organic acid metabolic process |
| negative regulation of cellular protein metabolic process |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| response to nitrogen compound |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| mitochondrion |
| regulation of hydrolase activity |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| response to endogenous stimulus |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| positive regulation of molecular function |
| cellular catabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| positive regulation of cellular biosynthetic process |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Quercetin 20μM R08 exp517 | -2.12 |
| Docosahexaenoic-acid 50μM R07 exp356 | 2.07 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6096
- Expression level (log2 read counts): 6.37
Expression Distribution
POR Expression in NALM6 Cells: 6.37
