PPIL4

Entrez Summary: N/A
UniProt Summary: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Methotrexate 0.01μM R08 exp501	-2.21
Celastrol 0.12μM R05 exp225	-2.1
NFN1 0.1μM R01 exp49	-1.99
UM0130462 0.025 to 0.035μM day4 R05 exp247	-1.94
Erlotinib 10μM R05 exp216	-1.92
YM155 0.0002μM R01 exp61	-1.86
Isoniazid 100μM R08 exp494	-1.76
Epigallocatechin gallate 20μM R05 exp230	-1.74
Salinomycin 3.5μM R08 exp521	1.86
S-DABN 8μM R03 exp112	1.96

Global Fraction of Cell Lines Where Essential: 362/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	11/28
blood	10/28
bone	10/26
breast	14/33
central nervous system	40/56
cervix	4/4
colorectal	5/17
esophagus	8/13
fibroblast	0/1
gastric	6/16
kidney	7/21
liver	4/20
lung	31/75
lymphocyte	12/16
ovary	19/26
pancreas	12/24
peripheral nervous system	12/16
plasma cell	11/15
prostate	0/1
skin	13/24
soft tissue	6/9
thyroid	2/2
upper aerodigestive	10/22
urinary tract	14/29
uterus	3/5

Expression Distribution