Pfam Domains GO Terms
| KRAB |
| SSXRD |
| regulation of reciprocal meiotic recombination |
| positive regulation of reciprocal meiotic recombination |
| positive regulation of meiosis I |
| regulation of meiosis I |
| positive regulation of meiotic nuclear division |
| histone methyltransferase activity (H3-K4 specific) |
| positive regulation of meiotic cell cycle |
| regulation of meiotic nuclear division |
| histone H3-K4 methylation |
| positive regulation of DNA recombination |
| regulation of meiotic cell cycle |
| positive regulation of nuclear division |
| chromatin DNA binding |
| histone lysine methylation |
| positive regulation of reproductive process |
| peptidyl-lysine methylation |
| histone methylation |
| regulation of DNA recombination |
| chromosome |
| protein methylation |
| protein alkylation |
| regulation of reproductive process |
| regulation of nuclear division |
| positive regulation of DNA metabolic process |
| macromolecule methylation |
| positive regulation of cell cycle process |
| methylation |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| peptidyl-lysine modification |
| regulation of DNA metabolic process |
| histone modification |
| covalent chromatin modification |
| positive regulation of cell cycle |
| sequence-specific DNA binding |
| positive regulation of organelle organization |
| DNA-binding transcription factor activity |
| chromatin organization |
| regulation of cell cycle process |
| peptidyl-amino acid modification |
| chromosome organization |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| positive regulation of nucleobase-containing compound metabolic process |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| GSK-J4 1-1.25μM to day4 R07 exp363 | -1.98 |
| ABT-702 5μM R07 exp318 | -1.81 |
| GSK343 3μM R03 exp124 | -1.79 |
| L-74142 5μM R03 exp131 | -1.75 |
| SGC0946 7μM R03 exp151 | 1.8 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution