PRIM2
Gene Information
- Official Symbol: PRIM2
- Official Name: DNA primase subunit 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 5558
- UniProt: P49643
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes the 58 kilodalton subunit of DNA primase, an enzyme that plays a key role in the replication of DNA. The encoded protein forms a heterodimer with a 49 kilodalton subunit. This heterodimer functions as a DNA-directed RNA polymerase to synthesize small RNA primers that are used to create Okazaki fragments on the lagging strand of the DNA. Alternative splicing of this gene results in multiple transcript variants. This gene has a related pseudogene, which is also present on chromosome 6. [provided by RefSeq, Apr 2014].
- UniProt Summary: DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 2238
- Expression level (log2 read counts): 4.92
PRIM2 Expression in NALM6 Cells: 4.92
