PRKAR2A
Gene Information
- Official Symbol: PRKAR2A
- Official Name: protein kinase cAMP-dependent type II regulatory subunit alpha
- Aliases and Previous Symbols: N/A
- Entrez ID: 5576
- UniProt: P13861
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Pfam Domains GO Terms
Pfam Domains
| cNMP binding |
| RIIa |
GO Terms
| cAMP-dependent protein kinase regulator activity |
| negative regulation of cAMP-dependent protein kinase activity |
| cAMP-dependent protein kinase inhibitor activity |
| cAMP-dependent protein kinase complex |
| protein kinase A catalytic subunit binding |
| nucleotide-activated protein kinase complex |
| 3,5-cyclic-GMP phosphodiesterase activity |
| regulation of cAMP-dependent protein kinase activity |
| activation of protein kinase A activity |
| cAMP binding |
| cGMP-mediated signaling |
| cellular response to glucagon stimulus |
| plasma membrane raft |
| ciliary base |
| renal water homeostasis |
| response to glucagon |
| multicellular organismal water homeostasis |
| water homeostasis |
| axoneme |
| renal system process |
| negative regulation of protein serine/threonine kinase activity |
| cyclic-nucleotide-mediated signaling |
| negative regulation of protein kinase activity |
| protein domain specific binding |
| negative regulation of kinase activity |
| cellular response to peptide hormone stimulus |
| negative regulation of transferase activity |
| blood coagulation |
| ubiquitin protein ligase binding |
| coagulation |
| hemostasis |
| multicellular organismal homeostasis |
| cellular response to peptide |
| activation of protein kinase activity |
| second-messenger-mediated signaling |
| response to peptide hormone |
| negative regulation of protein phosphorylation |
| focal adhesion |
| negative regulation of phosphorylation |
| response to peptide |
| wound healing |
| centrosome |
| regulation of body fluid levels |
| regulation of protein serine/threonine kinase activity |
| positive regulation of protein kinase activity |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| response to wounding |
| positive regulation of kinase activity |
| negative regulation of protein modification process |
| protein-containing complex |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| positive regulation of transferase activity |
| cellular response to nitrogen compound |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of kinase activity |
| response to hormone |
| regulation of transferase activity |
| response to organonitrogen compound |
| positive regulation of protein phosphorylation |
| negative regulation of cellular protein metabolic process |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| response to nitrogen compound |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| negative regulation of molecular function |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| homeostatic process |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| system process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Cerivastatin 0.15μM R05 exp226 | -1.81 |
| CB-5083 0.4μM R08 exp468 | 1.73 |
| Nicotine 3000μM R08 exp510 | 1.92 |
| CAY10603 0.55μM R08 exp467 | 2.1 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3281
- Expression level (log2 read counts): 5.54
Expression Distribution
PRKAR2A Expression in NALM6 Cells: 5.54
