PRKAR2B
Gene Information
- Official Symbol: PRKAR2B
- Official Name: protein kinase cAMP-dependent type II regulatory subunit beta
- Aliases and Previous Symbols: N/A
- Entrez ID: 5577
- UniProt: P31323
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Pfam Domains GO Terms
Pfam Domains
| RIIa |
| cNMP binding |
GO Terms
| response to clozapine |
| response to antipsychotic drug |
| cAMP-dependent protein kinase regulator activity |
| cAMP-dependent protein kinase inhibitor activity |
| negative regulation of cAMP-dependent protein kinase activity |
| cAMP-dependent protein kinase complex |
| protein kinase A catalytic subunit binding |
| 3,5-cyclic-GMP phosphodiesterase activity |
| regulation of cAMP-dependent protein kinase activity |
| activation of protein kinase A activity |
| cAMP binding |
| cGMP-mediated signaling |
| cellular response to glucagon stimulus |
| renal water homeostasis |
| ciliary base |
| response to glucagon |
| dendritic shaft |
| multicellular organismal water homeostasis |
| water homeostasis |
| ciliary basal body-plasma membrane docking |
| renal system process |
| G2/M transition of mitotic cell cycle |
| negative regulation of protein serine/threonine kinase activity |
| cell cycle G2/M phase transition |
| learning |
| dendritic spine |
| organelle localization by membrane tethering |
| cyclic-nucleotide-mediated signaling |
| membrane docking |
| regulation of G2/M transition of mitotic cell cycle |
| regulation of cell cycle G2/M phase transition |
| membrane raft |
| negative regulation of protein kinase activity |
| protein domain specific binding |
| negative regulation of kinase activity |
| learning or memory |
| cellular response to peptide hormone stimulus |
| mitotic cell cycle phase transition |
| negative regulation of transferase activity |
| cell cycle phase transition |
| blood coagulation |
| ubiquitin protein ligase binding |
| coagulation |
| hemostasis |
| cognition |
| response to xenobiotic stimulus |
| fatty acid metabolic process |
| multicellular organismal homeostasis |
| cellular response to peptide |
| activation of protein kinase activity |
| second-messenger-mediated signaling |
| cilium assembly |
| glutamatergic synapse |
| cilium organization |
| neuronal cell body |
| response to peptide hormone |
| negative regulation of protein phosphorylation |
| regulation of mitotic cell cycle phase transition |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| negative regulation of phosphorylation |
| plasma membrane bounded cell projection assembly |
| regulation of cell cycle phase transition |
| cell projection assembly |
| response to peptide |
| wound healing |
| centrosome |
| regulation of body fluid levels |
| regulation of protein serine/threonine kinase activity |
| monocarboxylic acid metabolic process |
| positive regulation of protein kinase activity |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| behavior |
| response to wounding |
| positive regulation of kinase activity |
| organelle localization |
| negative regulation of protein modification process |
| mitotic cell cycle process |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| regulation of mitotic cell cycle |
| positive regulation of transferase activity |
| cellular response to nitrogen compound |
| mitotic cell cycle |
| perinuclear region of cytoplasm |
| regulation of cell cycle process |
| organelle assembly |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of kinase activity |
| response to hormone |
| carboxylic acid metabolic process |
| response to organic cyclic compound |
| cellular lipid metabolic process |
| regulation of transferase activity |
| cell cycle process |
| response to organonitrogen compound |
| oxoacid metabolic process |
| positive regulation of protein phosphorylation |
| response to drug |
| organic acid metabolic process |
| negative regulation of cellular protein metabolic process |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| response to nitrogen compound |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| negative regulation of molecular function |
| cell projection organization |
| regulation of cell cycle |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| cell cycle |
| nervous system process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| homeostatic process |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| small molecule metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Senexin-A 25μM R07 exp400 | -2.01 |
| GSK461364A 0.1μM R03 exp126 | -1.72 |
| 1-Methyl-nicotinamide-chloride 1000μM R03 exp113 | 2.11 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14933
- Expression level (log2 read counts): 3.08
Expression Distribution
PRKAR2B Expression in NALM6 Cells: 3.08
