PROX1
Gene Information
- Official Symbol: PROX1
- Official Name: prospero homeobox 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 5629
- UniProt: Q92786
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. {ECO:0000269|PubMed:23723244, ECO:0000303|PubMed:22733308}.
Pfam Domains GO Terms
Pfam Domains
| Prox1 |
GO Terms
| branching involved in pancreas morphogenesis |
| acinar cell differentiation |
| positive regulation of forebrain neuron differentiation |
| otic placode formation |
| hepatocyte cell migration |
| optic placode formation |
| regulation of transcription involved in lymphatic endothelial cell fate commitment |
| optic placode formation involved in camera-type eye formation |
| olfactory placode formation |
| olfactory placode morphogenesis |
| lymphatic endothelial cell fate commitment |
| olfactory placode development |
| ventricular cardiac myofibril assembly |
| aorta smooth muscle tissue morphogenesis |
| DBD domain binding |
| negative regulation of bile acid metabolic process |
| positive regulation of sarcomere organization |
| negative regulation of bile acid biosynthetic process |
| epithelial cell proliferation involved in liver morphogenesis |
| hepatocyte proliferation |
| endocardium formation |
| pancreas morphogenesis |
| regulation of forebrain neuron differentiation |
| liver morphogenesis |
| lens fiber cell morphogenesis |
| atrial cardiac muscle tissue morphogenesis |
| endocardium morphogenesis |
| endothelial cell fate commitment |
| atrial cardiac muscle tissue development |
| cerebellar granule cell differentiation |
| LBD domain binding |
| regulation of sarcomere organization |
| cerebellar granular layer formation |
| embryonic retina morphogenesis in camera-type eye |
| lymphatic endothelial cell differentiation |
| otic vesicle formation |
| venous blood vessel morphogenesis |
| cerebellar granular layer morphogenesis |
| otic vesicle morphogenesis |
| positive regulation of cell cycle checkpoint |
| regulation of bile acid biosynthetic process |
| ventricular cardiac muscle cell development |
| ectodermal placode formation |
| ectodermal placode morphogenesis |
| regulation of bile acid metabolic process |
| ectodermal placode development |
| embryonic camera-type eye formation |
| lymphangiogenesis |
| endocardium development |
| cerebellar granular layer development |
| hepatocyte differentiation |
| lens fiber cell development |
| skeletal muscle thin filament assembly |
| epithelial cell fate commitment |
| otic vesicle development |
| venous blood vessel development |
| lymph vessel morphogenesis |
| nose development |
| ventricular cardiac muscle cell differentiation |
| skeletal myofibril assembly |
| dentate gyrus development |
| smooth muscle tissue development |
| regulation of transcription involved in cell fate commitment |
| cell differentiation in hindbrain |
| nuclear receptor binding |
| cerebellar cortex formation |
| dorsal spinal cord development |
| lens morphogenesis in camera-type eye |
| lymph vessel development |
| neuronal stem cell population maintenance |
| negative regulation of steroid biosynthetic process |
| cardiac myofibril assembly |
| negative regulation of steroid metabolic process |
| embryonic camera-type eye morphogenesis |
| lens fiber cell differentiation |
| aorta morphogenesis |
| cardiac atrium morphogenesis |
| cerebellar cortex morphogenesis |
| regulation of cell cycle checkpoint |
| positive regulation of cyclin-dependent protein serine/threonine kinase activity |
| embryonic eye morphogenesis |
| cardiac atrium development |
| positive regulation of cyclin-dependent protein kinase activity |
| cerebellum morphogenesis |
| embryonic camera-type eye development |
| positive regulation of heart growth |
| glandular epithelial cell differentiation |
| cell fate determination |
| ventricular septum morphogenesis |
| hindbrain morphogenesis |
| cerebellar cortex development |
| positive regulation of organ growth |
| ventricular cardiac muscle tissue morphogenesis |
| negative regulation of lipid biosynthetic process |
| retina morphogenesis in camera-type eye |
| aorta development |
| positive regulation of neural precursor cell proliferation |
| ventricular cardiac muscle tissue development |
| negative regulation of viral genome replication |
| positive regulation of striated muscle cell differentiation |
| cardiac muscle cell development |
| artery morphogenesis |
| regulation of heart growth |
| cardiac cell development |
| myofibril assembly |
| cardiac muscle tissue morphogenesis |
| pancreas development |
| ventricular septum development |
| cardiac ventricle morphogenesis |
| cardiac septum morphogenesis |
| positive regulation of organelle assembly |
| lens development in camera-type eye |
| muscle tissue morphogenesis |
| hippocampus development |
| negative regulation of viral life cycle |
| endothelial cell differentiation |
| negative regulation of lipid metabolic process |
| artery development |
| muscle organ morphogenesis |
| positive regulation of muscle cell differentiation |
| epithelial cell proliferation |
| regulation of steroid biosynthetic process |
| regulation of neural precursor cell proliferation |
| cardiac muscle cell differentiation |
| regulation of actomyosin structure organization |
| negative regulation of small molecule metabolic process |
| regulation of organ growth |
| regulation of viral genome replication |
| positive regulation of endothelial cell proliferation |
| endothelium development |
| columnar/cuboidal epithelial cell differentiation |
| inner ear morphogenesis |
| negative regulation of viral process |
| regulation of cyclin-dependent protein serine/threonine kinase activity |
| positive regulation of endothelial cell migration |
| gland morphogenesis |
| regulation of striated muscle cell differentiation |
| regulation of cyclin-dependent protein kinase activity |
| cerebellum development |
| cellular component assembly involved in morphogenesis |
| spinal cord development |
| cardiac septum development |
| limbic system development |
| metencephalon development |
| camera-type eye morphogenesis |
| regulation of circadian rhythm |
| actomyosin structure organization |
| regulation of steroid metabolic process |
| cardiocyte differentiation |
| ear morphogenesis |
| liver development |
| cardiac chamber morphogenesis |
| cardiac ventricle development |
| regulation of endothelial cell proliferation |
| hepaticobiliary system development |
| epithelial tube formation |
| striated muscle cell development |
| stem cell population maintenance |
| maintenance of cell number |
| retina development in camera-type eye |
| positive regulation of epithelial cell migration |
| circadian rhythm |
| regulation of viral life cycle |
| eye morphogenesis |
| tube formation |
| muscle cell development |
| hindbrain development |
| regulation of muscle cell differentiation |
| regulation of endothelial cell migration |
| morphogenesis of a branching epithelium |
| neural tube development |
| negative regulation of DNA-binding transcription factor activity |
| cardiac muscle tissue development |
| morphogenesis of a branching structure |
| lung development |
| cardiac chamber development |
| positive regulation of developmental growth |
| regulation of cellular ketone metabolic process |
| respiratory tube development |
| pallium development |
| central nervous system neuron differentiation |
| regulation of lipid biosynthetic process |
| positive regulation of epithelial cell proliferation |
| epithelial cell development |
| inner ear development |
| respiratory system development |
| positive regulation of supramolecular fiber organization |
| striated muscle cell differentiation |
| regulation of viral process |
| negative regulation of multi-organism process |
| transcription regulatory region DNA binding |
| regulation of symbiosis, encompassing mutualism through parasitism |
| positive regulation of cytoskeleton organization |
| regulation of epithelial cell migration |
| regulation of organelle assembly |
| ear development |
| actin filament organization |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| muscle cell differentiation |
| cell fate commitment |
| heart morphogenesis |
| sensory organ morphogenesis |
| telencephalon development |
| positive regulation of growth |
| kidney development |
| rhythmic process |
| renal system development |
| striated muscle tissue development |
| embryonic organ morphogenesis |
| muscle organ development |
| muscle tissue development |
| epithelial tube morphogenesis |
| camera-type eye development |
| urogenital system development |
| regulation of developmental growth |
| regulation of epithelial cell proliferation |
| positive regulation of protein serine/threonine kinase activity |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| eye development |
| visual system development |
| positive regulation of neuron differentiation |
| sensory system development |
| positive regulation of cell cycle |
| forebrain development |
| regulation of actin filament-based process |
| regulation of lipid metabolic process |
| blood vessel morphogenesis |
| gland development |
| regulation of DNA-binding transcription factor activity |
| regulation of small molecule metabolic process |
| morphogenesis of an epithelium |
| embryonic organ development |
| supramolecular fiber organization |
| positive regulation of neurogenesis |
| muscle structure development |
| blood vessel development |
| actin cytoskeleton organization |
| response to nutrient levels |
| positive regulation of cell migration |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| vasculature development |
| regulation of protein serine/threonine kinase activity |
| cardiovascular system development |
| positive regulation of cellular component biogenesis |
| positive regulation of cell motility |
| heart development |
| response to extracellular stimulus |
| positive regulation of protein kinase activity |
| positive regulation of nervous system development |
| positive regulation of cellular component movement |
| regulation of cytoskeleton organization |
| positive regulation of cell development |
| sensory organ development |
| positive regulation of locomotion |
| cell population proliferation |
| cell morphogenesis involved in differentiation |
| tissue morphogenesis |
| embryonic morphogenesis |
| actin filament-based process |
| positive regulation of kinase activity |
| positive regulation of organelle organization |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| positive regulation of transferase activity |
| regulation of neuron differentiation |
| regulation of growth |
| DNA-binding transcription factor activity |
| negative regulation of cell population proliferation |
| epithelial cell differentiation |
| cell morphogenesis |
| brain development |
| organelle assembly |
| regulation of multi-organism process |
| head development |
| regulation of protein kinase activity |
| regulation of neurogenesis |
| cellular component morphogenesis |
| tube development |
| regulation of cell migration |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| regulation of kinase activity |
| anatomical structure formation involved in morphogenesis |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| regulation of cell development |
| animal organ morphogenesis |
| regulation of cellular component biogenesis |
| cell migration |
| positive regulation of cell differentiation |
| embryo development |
| regulation of transferase activity |
| central nervous system development |
| regulation of locomotion |
| regulation of cellular component movement |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cell motility |
| localization of cell |
| cytoskeleton organization |
| epithelium development |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| negative regulation of molecular function |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| regulation of organelle organization |
| locomotion |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Ethanol 0.003 R08 exp437 | -1.87 |
| UM131593 0.2μM R03 exp106 | -1.86 |
| Taxol 0.004μM R03 exp103 | -1.81 |
| A-769662 20μM R07 exp331 | 1.85 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5836
- Expression level (log2 read counts): 0.75
Expression Distribution
PROX1 Expression in NALM6 Cells: 0.75
