PSMG1

Entrez Summary: N/A
UniProt Summary: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. {ECO:0000269|PubMed:16251969, ECO:0000269|PubMed:17707236}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
BI-6727 0.001μM R01 exp42	2.29

Gene	Correlation
PSMG2	0.443

Global Fraction of Cell Lines Where Essential: 240/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	10/28
blood	6/28
bone	5/26
breast	15/33
central nervous system	14/56
cervix	1/4
colorectal	7/17
esophagus	8/13
fibroblast	0/1
gastric	5/16
kidney	2/21
liver	9/20
lung	19/75
lymphocyte	5/16
ovary	9/26
pancreas	12/24
peripheral nervous system	3/16
plasma cell	2/15
prostate	0/1
skin	12/24
soft tissue	5/9
thyroid	0/2
upper aerodigestive	10/22
urinary tract	13/29
uterus	2/5

Expression Distribution