PURB
Gene Information
- Official Symbol: PURB
- Official Name: purine rich element binding protein B
- Aliases and Previous Symbols: N/A
- Entrez ID: 5814
- UniProt: Q96QR8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Has capacity to bind repeated elements in single- stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine- rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity). {ECO:0000250, ECO:0000269|PubMed:1448097}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 15148
- Expression level (log2 read counts): 7.33
PURB Expression in NALM6 Cells: 7.33
