QTRT1
Gene Information
- Official Symbol: QTRT1
- Official Name: queuine tRNA-ribosyltransferase catalytic subunit 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 81890
- UniProt: Q9BXR0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (PubMed:11255023, PubMed:20354154). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product (By similarity). {ECO:0000250|UniProtKB:P28720, ECO:0000255|HAMAP- Rule:MF_03218, ECO:0000269|PubMed:11255023, ECO:0000269|PubMed:20354154}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 7725
- Expression level (log2 read counts): 5.49
QTRT1 Expression in NALM6 Cells: 5.49
