RGMA
Gene Information
- Official Symbol: RGMA
- Official Name: repulsive guidance molecule BMP co-receptor a
- Aliases and Previous Symbols: N/A
- Entrez ID: 56963
- UniProt: Q96B86
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| RGM C |
| RGM N |
GO Terms
| transferrin receptor binding |
| negative regulation of axon regeneration |
| negative regulation of neuron projection regeneration |
| regulation of axon regeneration |
| regulation of neuron projection regeneration |
| coreceptor activity |
| negative regulation of response to wounding |
| BMP signaling pathway |
| anchored component of membrane |
| response to BMP |
| cellular response to BMP stimulus |
| negative regulation of neuron projection development |
| regulation of response to wounding |
| negative regulation of cell projection organization |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| negative regulation of neuron differentiation |
| negative regulation of neurogenesis |
| negative regulation of nervous system development |
| negative regulation of cell development |
| negative regulation of response to external stimulus |
| regulation of neuron projection development |
| cellular response to growth factor stimulus |
| response to growth factor |
| regulation of neuron differentiation |
| regulation of plasma membrane bounded cell projection organization |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| regulation of cellular response to stress |
| regulation of neurogenesis |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| endoplasmic reticulum |
| regulation of response to external stimulus |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| response to endogenous stimulus |
| regulation of response to stress |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of RNA metabolic process |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| R-DABN 8μM R03 exp111 | -2.11 |
| CCT251545 20μM R07 exp326 | -1.82 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9546
- Expression level (log2 read counts): 4.67
Expression Distribution
RGMA Expression in NALM6 Cells: 4.67
