Entrez Summary: This gene is located in a cluster of Ran-binding protein related genes on chromosome 2 which arose through duplication in primates. The encoded protein contains an N-terminal TPR (tetratricopeptide repeat) domain, two Ran-binding domains, and a C-terminal GRIP domain (golgin-97, RanBP2alpha, Imh1p and p230/golgin-245) domain. [provided by RefSeq, Sep 2011].
UniProt Summary: N/A
Pfam DomainsGO Terms
Pfam Domains
TPR 1
GRIP
Ran BP1
GO Terms
NLS-bearing protein import into nucleus
Ran GTPase binding
nuclear pore
protein import into nucleus
import into nucleus
protein import
protein localization to nucleus
nucleocytoplasmic transport
nuclear transport
GTPase activator activity
positive regulation of GTPase activity
establishment of protein localization to organelle
regulation of GTPase activity
protein localization to organelle
positive regulation of hydrolase activity
intracellular protein transport
regulation of hydrolase activity
positive regulation of catalytic activity
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
positive regulation of molecular function
establishment of localization in cell
nitrogen compound transport
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)