RHOBTB1
Gene Information
- Official Symbol: RHOBTB1
- Official Name: Rho related BTB domain containing 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 9886
- UniProt: O94844
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| BTB |
| Miro |
| Ras |
GO Terms
| engulfment of apoptotic cell |
| apoptotic cell clearance |
| actin cytoskeleton reorganization |
| Rho protein signal transduction |
| positive regulation of actin filament polymerization |
| cell projection |
| positive regulation of protein polymerization |
| phagocytosis, engulfment |
| plasma membrane invagination |
| membrane invagination |
| regulation of actin filament polymerization |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| positive regulation of supramolecular fiber organization |
| positive regulation of cytoskeleton organization |
| regulation of protein polymerization |
| actin filament organization |
| Ras protein signal transduction |
| positive regulation of protein complex assembly |
| regulation of actin filament organization |
| small GTPase mediated signal transduction |
| phagocytosis |
| GTPase activity |
| regulation of actin cytoskeleton organization |
| regulation of small GTPase mediated signal transduction |
| regulation of supramolecular fiber organization |
| cytoskeleton |
| regulation of cellular component size |
| regulation of actin filament-based process |
| GTP binding |
| regulation of protein complex assembly |
| supramolecular fiber organization |
| protein kinase binding |
| actin cytoskeleton organization |
| regulation of anatomical structure size |
| positive regulation of cellular component biogenesis |
| regulation of cytoskeleton organization |
| endocytosis |
| actin filament-based process |
| positive regulation of organelle organization |
| import into cell |
| cell morphogenesis |
| cellular component morphogenesis |
| membrane organization |
| regulation of cellular component biogenesis |
| cell migration |
| localization of cell |
| cell motility |
| cytoskeleton organization |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| locomotion |
| movement of cell or subcellular component |
| intracellular signal transduction |
| regulation of intracellular signal transduction |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Colchicine 0.009μM R05 exp215 | -2.64 |
| Bortezomib 0.005μM R00 exp6 | -2.43 |
| DABN 20μM R00 exp17 | -2.07 |
| BML-284 0.09μM R08 exp460 | -1.72 |
| Phenformin 20μM R03 exp143 | 1.73 |
| Phenformin 20μM R05 exp212 | 1.73 |
| QNZ 0.01μM R08 exp439 | 2.19 |
| Rotenone 0.07μM R08 exp431 | 2.55 |
| Mubritinib 0.2μM R01 exp48 | 2.86 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18208
- Expression level (log2 read counts): 5.55
Expression Distribution
RHOBTB1 Expression in NALM6 Cells: 5.55
