RND2
Gene Information
- Official Symbol: RND2
- Official Name: Rho family GTPase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 8153
- UniProt: P52198
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| Ras |
| Miro |
| Arf |
GO Terms
| cell division site |
| positive regulation of collateral sprouting |
| establishment or maintenance of actin cytoskeleton polarity |
| establishment or maintenance of cytoskeleton polarity |
| acrosomal membrane |
| regulation of collateral sprouting |
| actin filament bundle assembly |
| actin filament bundle organization |
| Rho protein signal transduction |
| positive regulation of axonogenesis |
| protein N-terminus binding |
| regulation of extent of cell growth |
| cell cortex |
| regulation of cell shape |
| positive regulation of cell morphogenesis involved in differentiation |
| positive regulation of cell growth |
| positive regulation of developmental growth |
| regulation of cell size |
| regulation of axonogenesis |
| establishment or maintenance of cell polarity |
| actin filament organization |
| Ras protein signal transduction |
| early endosome |
| positive regulation of growth |
| positive regulation of neuron projection development |
| regulation of cell morphogenesis involved in differentiation |
| small GTPase mediated signal transduction |
| regulation of developmental growth |
| GTPase activity |
| regulation of actin cytoskeleton organization |
| positive regulation of neuron differentiation |
| regulation of cellular component size |
| positive regulation of cell projection organization |
| regulation of actin filament-based process |
| GTP binding |
| regulation of cell growth |
| supramolecular fiber organization |
| protein kinase binding |
| positive regulation of neurogenesis |
| regulation of cell morphogenesis |
| actin cytoskeleton organization |
| regulation of neuron projection development |
| regulation of anatomical structure size |
| positive regulation of nervous system development |
| regulation of cytoskeleton organization |
| positive regulation of cell development |
| actin filament-based process |
| regulation of neuron differentiation |
| regulation of growth |
| intracellular membrane-bounded organelle |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| regulation of neurogenesis |
| regulation of cell migration |
| regulation of cell motility |
| regulation of nervous system development |
| regulation of cell development |
| positive regulation of cell differentiation |
| regulation of locomotion |
| regulation of cellular component movement |
| regulation of anatomical structure morphogenesis |
| cytoskeleton organization |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| positive regulation of developmental process |
| generation of neurons |
| neurogenesis |
| intracellular signal transduction |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| PF-06409577 20μM R07 exp389 | 1.74 |
| Senexin-A 25μM R07 exp400 | 1.82 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 2/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15068
- Expression level (log2 read counts): 2.0
Expression Distribution
RND2 Expression in NALM6 Cells: 2.0
