RNF207
Gene Information
- Official Symbol: RNF207
- Official Name: ring finger protein 207
- Aliases and Previous Symbols: N/A
- Entrez ID: 388591
- UniProt: Q6ZRF8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner. {ECO:0000269|PubMed:25281747}.
Pfam Domains GO Terms
Pfam Domains
| zf-B box |
GO Terms
| regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization |
| positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization |
| regulation of heart looping |
| positive regulation of atrial cardiac muscle cell action potential |
| positive regulation of membrane repolarization during cardiac muscle cell action potential |
| positive regulation of ventricular cardiac muscle cell action potential |
| positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential |
| positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization |
| regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization |
| positive regulation of cardiac conduction |
| positive regulation of actin filament-based movement |
| positive regulation of delayed rectifier potassium channel activity |
| regulation of membrane repolarization during ventricular cardiac muscle cell action potential |
| positive regulation of cardiac muscle cell contraction |
| regulation of membrane repolarization during cardiac muscle cell action potential |
| regulation of atrial cardiac muscle cell action potential |
| regulation of membrane repolarization during action potential |
| positive regulation of action potential |
| positive regulation of cardiac muscle contraction |
| positive regulation of striated muscle contraction |
| regulation of ventricular cardiac muscle cell action potential |
| positive regulation of voltage-gated potassium channel activity |
| regulation of delayed rectifier potassium channel activity |
| regulation of ventricular cardiac muscle cell membrane repolarization |
| positive regulation of potassium ion transmembrane transporter activity |
| regulation of cardiac muscle cell membrane repolarization |
| cell-cell signaling involved in cardiac conduction |
| regulation of cardiac muscle cell action potential |
| regulation of membrane repolarization |
| regulation of cardiac muscle cell contraction |
| positive regulation of potassium ion transmembrane transport |
| positive regulation of heart contraction |
| regulation of heart morphogenesis |
| regulation of actin filament-based movement |
| Hsp70 protein binding |
| cell communication involved in cardiac conduction |
| positive regulation of muscle contraction |
| positive regulation of potassium ion transport |
| regulation of action potential |
| regulation of potassium ion transmembrane transporter activity |
| regulation of cardiac conduction |
| positive regulation of cation channel activity |
| positive regulation of blood circulation |
| regulation of cardiac muscle contraction |
| regulation of potassium ion transmembrane transport |
| regulation of striated muscle contraction |
| cardiac conduction |
| regulation of potassium ion transport |
| chaperone binding |
| positive regulation of ion transmembrane transporter activity |
| positive regulation of transporter activity |
| ion channel binding |
| regulation of embryonic development |
| multicellular organismal signaling |
| positive regulation of cation transmembrane transport |
| positive regulation of ion transmembrane transport |
| regulation of muscle contraction |
| regulation of cation channel activity |
| regulation of morphogenesis of an epithelium |
| positive regulation of transmembrane transport |
| regulation of muscle system process |
| regulation of heart contraction |
| regulation of ion transmembrane transporter activity |
| regulation of animal organ morphogenesis |
| regulation of transmembrane transporter activity |
| positive regulation of ion transport |
| regulation of transporter activity |
| regulation of blood circulation |
| regulation of cation transmembrane transport |
| regulation of metal ion transport |
| regulation of actin filament-based process |
| regulation of membrane potential |
| regulation of ion transmembrane transport |
| positive regulation of cellular component movement |
| regulation of transmembrane transport |
| regulation of system process |
| perinuclear region of cytoplasm |
| regulation of ion transport |
| zinc ion binding |
| positive regulation of transport |
| regulation of cellular component movement |
| regulation of anatomical structure morphogenesis |
| cell-cell signaling |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of transport |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Lead acetate 2000μM R08 exp497 | -1.93 |
| HMS-I1 10μM R06 exp256 | -1.71 |
| Pterostilbene 16μM R02 exp78 | 1.71 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4974
- Expression level (log2 read counts): 2.77
Expression Distribution
RNF207 Expression in NALM6 Cells: 2.77
