RPRD1A

Entrez Summary: N/A
UniProt Summary: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. {ECO:0000269|PubMed:22231121, ECO:0000269|PubMed:24399136, ECO:0000269|PubMed:24997600}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.11 to 0.175μM on day4 R07 exp413	-2.06
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.93
Nicotinamide 2000μM R01 exp50	-1.87
Dinaciclib 0.007μM R07 exp355	-1.75
THZ531 0.11 to 0.125μM on day4 R07 exp410	-1.74
AICAR 240μM R03 exp116	1.72
GSK626616 14μM R08 exp485	1.74
A-395 10μM R05 exp218	1.87
Dimethyl-Sulfoxide 1pc R03 exp120	1.95

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution