RUNX3
Gene Information
- Official Symbol: RUNX3
- Official Name: RUNX family transcription factor 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 864
- UniProt: Q13761
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters. In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). {ECO:0000269|PubMed:20599712}.
Pfam Domains GO Terms
Pfam Domains
| RunxI |
| Runt |
GO Terms
| core-binding factor complex |
| positive regulation of CD8-positive, alpha-beta T cell differentiation |
| positive regulation of CD8-positive, alpha-beta T cell activation |
| regulation of CD8-positive, alpha-beta T cell differentiation |
| peripheral nervous system neuron development |
| peripheral nervous system neuron differentiation |
| regulation of CD8-positive, alpha-beta T cell activation |
| negative regulation of CD4-positive, alpha-beta T cell differentiation |
| negative regulation of alpha-beta T cell differentiation |
| negative regulation of CD4-positive, alpha-beta T cell activation |
| negative regulation of alpha-beta T cell activation |
| negative regulation of T cell differentiation |
| regulation of CD4-positive, alpha-beta T cell differentiation |
| positive regulation of alpha-beta T cell differentiation |
| negative regulation of lymphocyte differentiation |
| positive regulation of alpha-beta T cell activation |
| regulation of CD4-positive, alpha-beta T cell activation |
| regulation of alpha-beta T cell differentiation |
| peripheral nervous system development |
| positive regulation of T cell differentiation |
| chondrocyte differentiation |
| regulation of alpha-beta T cell activation |
| positive regulation of lymphocyte differentiation |
| negative regulation of leukocyte differentiation |
| negative regulation of T cell activation |
| negative regulation of leukocyte cell-cell adhesion |
| negative regulation of epithelial cell proliferation |
| negative regulation of hemopoiesis |
| regulation of T cell differentiation |
| negative regulation of lymphocyte activation |
| positive regulation of leukocyte differentiation |
| response to transforming growth factor beta |
| regulation of lymphocyte differentiation |
| cartilage development |
| negative regulation of leukocyte activation |
| negative regulation of cell-cell adhesion |
| positive regulation of hemopoiesis |
| negative regulation of cell activation |
| positive regulation of T cell activation |
| positive regulation of leukocyte cell-cell adhesion |
| connective tissue development |
| nuclear chromatin |
| positive regulation of cell-cell adhesion |
| negative regulation of cell adhesion |
| regulation of leukocyte differentiation |
| regulation of leukocyte cell-cell adhesion |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| regulation of T cell activation |
| regulation of epithelial cell proliferation |
| positive regulation of lymphocyte activation |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell activation |
| negative regulation of immune system process |
| regulation of hemopoiesis |
| transcription by RNA polymerase II |
| skeletal system development |
| regulation of lymphocyte activation |
| response to growth factor |
| hemopoiesis |
| negative regulation of cell cycle |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| transcription, DNA-templated |
| regulation of cell activation |
| nucleic acid-templated transcription |
| immune system development |
| RNA biosynthetic process |
| DNA-binding transcription factor activity |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| intracellular membrane-bounded organelle |
| negative regulation of cell differentiation |
| neuron development |
| nucleolus |
| negative regulation of transcription by RNA polymerase II |
| negative regulation of developmental process |
| positive regulation of cell differentiation |
| protein phosphorylation |
| neuron differentiation |
| nucleobase-containing compound biosynthetic process |
| positive regulation of immune system process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| phosphorylation |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| ATP binding |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of cell population proliferation |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| regulation of immune system process |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| macromolecule biosynthetic process |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| proTAME 5μM R04 exp187 | -2.33 |
| Nocodazole 0.2μM R02 exp64 | -1.92 |
| CCCP 1μM R00 exp11 | -1.76 |
| Calcium Ionophore 0.4μM R07 exp342 | -1.72 |
| CB-839 10μM R05 exp224 | 1.83 |
| S-trityl-L-cysteine 0.5μM R05 exp243 | 2.13 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8470
- Expression level (log2 read counts): 1.05
Expression Distribution
RUNX3 Expression in NALM6 Cells: 1.05
