SAMD9
Gene Information
- Official Symbol: SAMD9
- Official Name: sterile alpha motif domain containing 9
- Aliases and Previous Symbols: N/A
- Entrez ID: 54809
- UniProt: Q5K651
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a sterile alpha motif domain-containing protein. The encoded protein localizes to the cytoplasm and may play a role in regulating cell proliferation and apoptosis. Mutations in this gene are the cause of normophosphatemic familial tumoral calcinosis. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Jul 2010].
- UniProt Summary: May play a role in the inflammatory response to tissue injury and the control of extra-osseous calcification, acting as a downstream target of TNF-alpha signaling. Involved in the regulation of EGR1, in coordination with RGL2. May be involved in endosome fusion. {ECO:0000269|PubMed:16960814, ECO:0000269|PubMed:18094730, ECO:0000269|PubMed:21160498, ECO:0000269|PubMed:24029230}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 8517
- Expression level (log2 read counts): 5.77
SAMD9 Expression in NALM6 Cells: 5.77
