SDCBP2
Gene Information
- Official Symbol: SDCBP2
- Official Name: syndecan binding protein 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 27111
- UniProt: Q9H190
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene contains two class II PDZ domains. PDZ domains facilitate protein-protein interactions by binding to the cytoplasmic C-terminus of transmembrane proteins, and PDZ-containing proteins mediate cell signaling and the organization of protein complexes. The encoded protein binds to phosphatidylinositol 4, 5-bisphosphate (PIP2) and plays a role in nuclear PIP2 organization and cell division. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Read-through transcription also exists between this gene and the upstream FKBP1A (FK506 binding protein 1A, 12kDa) gene, as represented in GeneID:100528031. [provided by RefSeq, Sep 2011].
- UniProt Summary: Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival (PubMed:15961997). {ECO:0000269|PubMed:15961997}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 9548
- Expression level (log2 read counts): -0.18
SDCBP2 Expression in NALM6 Cells: -0.18
