SDHB
Gene Information
- Official Symbol: SDHB
- Official Name: succinate dehydrogenase complex iron sulfur subunit B
- Aliases and Previous Symbols: N/A
- Entrez ID: 6390
- UniProt: P21912
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008].
- UniProt Summary: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 1197
- Expression level (log2 read counts): 6.14
SDHB Expression in NALM6 Cells: 6.14
