SDHC
Gene Information
- Official Symbol: SDHC
- Official Name: succinate dehydrogenase complex subunit C
- Aliases and Previous Symbols: N/A
- Entrez ID: 6391
- UniProt: Q99643
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2013]. COMPLETENESS: complete on the 3' end.
- UniProt Summary: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 667
- Expression level (log2 read counts): 6.42
SDHC Expression in NALM6 Cells: 6.42
