SEC61B
Gene Information
- Official Symbol: SEC61B
- Official Name: SEC61 translocon subunit beta
- Aliases and Previous Symbols: N/A
- Entrez ID: 10952
- UniProt: P60468
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Necessary for protein translocation in the endoplasmic reticulum.
Pfam Domains GO Terms
Pfam Domains
| Sec61 beta |
GO Terms
| endoplasmic reticulum Sec complex |
| epidermal growth factor binding |
| posttranslational protein targeting to membrane, translocation |
| Sec61 translocon complex |
| SRP-dependent cotranslational protein targeting to membrane, translocation |
| P-P-bond-hydrolysis-driven protein transmembrane transporter activity |
| posttranslational protein targeting to endoplasmic reticulum membrane |
| retrograde protein transport, ER to cytosol |
| endoplasmic reticulum to cytosol transport |
| ARF guanyl-nucleotide exchange factor activity |
| protein exit from endoplasmic reticulum |
| intracellular protein transmembrane transport |
| protein transmembrane transport |
| ubiquitin-dependent ERAD pathway |
| ERAD pathway |
| SRP-dependent cotranslational protein targeting to membrane |
| cotranslational protein targeting to membrane |
| protein targeting to ER |
| establishment of protein localization to endoplasmic reticulum |
| protein localization to endoplasmic reticulum |
| protein targeting to membrane |
| response to endoplasmic reticulum stress |
| establishment of protein localization to membrane |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| proteasomal protein catabolic process |
| protein targeting |
| establishment of protein localization to organelle |
| protein localization to membrane |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| proteolysis involved in cellular protein catabolic process |
| cellular protein catabolic process |
| protein catabolic process |
| protein localization to organelle |
| cellular macromolecule catabolic process |
| endoplasmic reticulum membrane |
| intracellular protein transport |
| response to organonitrogen compound |
| endoplasmic reticulum |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| response to nitrogen compound |
| proteolysis |
| transmembrane transport |
| RNA binding |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| cellular response to stress |
| organic substance catabolic process |
| cellular catabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 22/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 1/28 |
| bone | 4/26 |
| breast | 0/33 |
| central nervous system | 1/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 1/21 |
| liver | 2/20 |
| lung | 1/75 |
| lymphocyte | 0/16 |
| ovary | 2/26 |
| pancreas | 0/24 |
| peripheral nervous system | 2/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1810
- Expression level (log2 read counts): 5.95
Expression Distribution
SEC61B Expression in NALM6 Cells: 5.95
