SHMT1
Gene Information
- Official Symbol: SHMT1
- Official Name: serine hydroxymethyltransferase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6470
- UniProt: P34896
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
- UniProt Summary: Interconversion of serine and glycine (PubMed:8505317, PubMed:24698160). {ECO:0000269|PubMed:24698160, ECO:0000269|PubMed:8505317}.
Pfam Domains GO Terms
Pfam Domains
| SHMT |
GO Terms
| L-allo-threonine aldolase activity |
| glycine biosynthetic process from serine |
| response to tetrahydrofolate |
| glycine hydroxymethyltransferase activity |
| cellular response to tetrahydrofolate |
| cobalt ion binding |
| serine binding |
| dTMP metabolic process |
| glycine biosynthetic process |
| dTMP biosynthetic process |
| L-serine catabolic process |
| carnitine biosynthetic process |
| pyrimidine deoxyribonucleoside monophosphate biosynthetic process |
| pyrimidine deoxyribonucleoside monophosphate metabolic process |
| amino-acid betaine biosynthetic process |
| pyrimidine deoxyribonucleotide biosynthetic process |
| deoxyribonucleoside monophosphate biosynthetic process |
| tetrahydrofolate interconversion |
| purine nucleobase biosynthetic process |
| deoxyribose phosphate biosynthetic process |
| L-serine metabolic process |
| 2-deoxyribonucleotide biosynthetic process |
| deoxyribonucleoside monophosphate metabolic process |
| carnitine metabolic process |
| serine family amino acid catabolic process |
| deoxyribonucleotide biosynthetic process |
| translation repressor activity, mRNA regulatory element binding |
| pyrimidine nucleoside monophosphate biosynthetic process |
| pyrimidine nucleoside monophosphate metabolic process |
| serine family amino acid biosynthetic process |
| amino acid binding |
| amino-acid betaine metabolic process |
| glycine metabolic process |
| tetrahydrofolate metabolic process |
| nucleobase biosynthetic process |
| folic acid metabolic process |
| pyrimidine deoxyribonucleotide metabolic process |
| purine nucleobase metabolic process |
| mRNA 5-UTR binding |
| one-carbon metabolic process |
| folic acid-containing compound metabolic process |
| 2-deoxyribonucleotide metabolic process |
| deoxyribose phosphate metabolic process |
| pteridine-containing compound metabolic process |
| deoxyribonucleotide metabolic process |
| serine family amino acid metabolic process |
| nucleobase metabolic process |
| neurotransmitter biosynthetic process |
| nucleoside monophosphate biosynthetic process |
| cellular modified amino acid biosynthetic process |
| pyrimidine nucleotide biosynthetic process |
| pigment biosynthetic process |
| pyridoxal phosphate binding |
| pyrimidine-containing compound biosynthetic process |
| pyrimidine nucleotide metabolic process |
| pigment metabolic process |
| alpha-amino acid biosynthetic process |
| nucleoside monophosphate metabolic process |
| cellular amino acid biosynthetic process |
| water-soluble vitamin metabolic process |
| neurotransmitter metabolic process |
| protein homotetramerization |
| cellular response to leukemia inhibitory factor |
| response to leukemia inhibitory factor |
| dicarboxylic acid metabolic process |
| pyrimidine-containing compound metabolic process |
| alpha-amino acid catabolic process |
| vitamin metabolic process |
| cellular amino acid catabolic process |
| negative regulation of translation |
| negative regulation of cellular amide metabolic process |
| protein tetramerization |
| purine-containing compound biosynthetic process |
| ammonium ion metabolic process |
| cellular modified amino acid metabolic process |
| cellular response to acid chemical |
| alpha-amino acid metabolic process |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| coenzyme metabolic process |
| carboxylic acid catabolic process |
| organic acid catabolic process |
| carboxylic acid biosynthetic process |
| organic acid biosynthetic process |
| cellular amino acid metabolic process |
| protein homooligomerization |
| response to acid chemical |
| regulation of translation |
| regulation of neurotransmitter levels |
| purine-containing compound metabolic process |
| regulation of cellular amide metabolic process |
| small molecule catabolic process |
| cofactor metabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| drug metabolic process |
| protein complex oligomerization |
| posttranscriptional regulation of gene expression |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| cellular response to organic cyclic compound |
| small molecule biosynthetic process |
| cellular response to organonitrogen compound |
| carbohydrate derivative biosynthetic process |
| cellular response to nitrogen compound |
| cellular amide metabolic process |
| zinc ion binding |
| protein homodimerization activity |
| organophosphate metabolic process |
| carboxylic acid metabolic process |
| response to organic cyclic compound |
| response to organonitrogen compound |
| oxoacid metabolic process |
| cellular response to cytokine stimulus |
| organic acid metabolic process |
| carbohydrate derivative metabolic process |
| negative regulation of cellular protein metabolic process |
| cellular response to oxygen-containing compound |
| organonitrogen compound catabolic process |
| identical protein binding |
| response to nitrogen compound |
| nucleobase-containing compound biosynthetic process |
| response to cytokine |
| negative regulation of protein metabolic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| cellular response to endogenous stimulus |
| organic cyclic compound biosynthetic process |
| negative regulation of cellular macromolecule biosynthetic process |
| organonitrogen compound biosynthetic process |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| cellular nitrogen compound biosynthetic process |
| negative regulation of gene expression |
| small molecule metabolic process |
| organic substance catabolic process |
| cellular catabolic process |
| protein-containing complex subunit organization |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| UMK57 0.6μM R03 exp107 | -1.89 |
| BAY-598 4μM R05 exp220 | -1.82 |
| Mubritinib 0.2μM R02 exp65 | 1.75 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9245
- Expression level (log2 read counts): 5.77
Expression Distribution
SHMT1 Expression in NALM6 Cells: 5.77
