SHROOM3
Gene Information
- Official Symbol: SHROOM3
- Official Name: shroom family member 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 57619
- UniProt: Q8TF72
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a PDZ-domain-containing protein that belongs to a family of Shroom-related proteins. This protein may be involved in regulating cell shape in certain tissues. A similar protein in mice is required for proper neurulation. [provided by RefSeq, Jan 2011].
- UniProt Summary: Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 5796
- Expression level (log2 read counts): 1.67
SHROOM3 Expression in NALM6 Cells: 1.67
