SLC25A11
Gene Information
- Official Symbol: SLC25A11
- Official Name: solute carrier family 25 member 11
- Aliases and Previous Symbols: N/A
- Entrez ID: 8402
- UniProt: Q02978
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (PubMed:21448454). Involved in the regulation of apoptosis (By similarity). {ECO:0000250|UniProtKB:P97700, ECO:0000250|UniProtKB:Q9CR62, ECO:0000269|PubMed:21448454}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 5729
- Expression level (log2 read counts): 5.59
SLC25A11 Expression in NALM6 Cells: 5.59
