SLC25A24
Gene Information
- Official Symbol: SLC25A24
- Official Name: solute carrier family 25 member 24
- Aliases and Previous Symbols: N/A
- Entrez ID: 29957
- UniProt: Q6NUK1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a carrier protein that transports ATP-Mg exchanging it for phosphate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].
- UniProt Summary: Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress- induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitochondrial matrix, and thereby buffering calcium levels in the mitochondrial matrix. {ECO:0000269|PubMed:15123600, ECO:0000269|PubMed:22015608}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 13538
- Expression level (log2 read counts): 3.98
SLC25A24 Expression in NALM6 Cells: 3.98
