Entrez Summary: This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. Two transcript variants, one protein-coding and one not, have been found for this gene. [provided by RefSeq, Feb 2015].
UniProt Summary: Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1.
Pfam DomainsGO Terms
Pfam Domains
SSF
GO Terms
low-affinity glucose:sodium symporter activity
glucose:sodium symporter activity
glucose transmembrane transport
hexose transmembrane transport
monosaccharide transmembrane transport
carbohydrate transmembrane transport
carbohydrate transport
sodium ion transport
monovalent inorganic cation transport
carbohydrate metabolic process
metal ion transport
cation transport
transmembrane transport
ion transport
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)