SLK
Gene Information
- Official Symbol: SLK
- Official Name: STE20 like kinase
- Aliases and Previous Symbols: N/A
- Entrez ID: 9748
- UniProt: Q9H2G2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| PKK |
| Pkinase |
| Pkinase Tyr |
GO Terms
| cell leading edge |
| cytoplasmic microtubule organization |
| regulation of cell-substrate junction assembly |
| regulation of focal adhesion assembly |
| regulation of adherens junction organization |
| regulation of cell junction assembly |
| regulation of cell-matrix adhesion |
| stress-activated protein kinase signaling cascade |
| protein autophosphorylation |
| regulation of cell-substrate adhesion |
| cadherin binding |
| activation of protein kinase activity |
| protein serine/threonine kinase activity |
| signal transduction by protein phosphorylation |
| supramolecular fiber organization |
| microtubule cytoskeleton organization |
| positive regulation of protein kinase activity |
| positive regulation of kinase activity |
| positive regulation of transferase activity |
| microtubule-based process |
| regulation of cell adhesion |
| perinuclear region of cytoplasm |
| regulation of protein kinase activity |
| regulation of cell migration |
| regulation of kinase activity |
| protein homodimerization activity |
| regulation of cell motility |
| apoptotic process |
| regulation of cellular component biogenesis |
| protein phosphorylation |
| regulation of transferase activity |
| regulation of locomotion |
| regulation of cellular component movement |
| positive regulation of protein phosphorylation |
| programmed cell death |
| positive regulation of phosphorylation |
| identical protein binding |
| cell death |
| cytoskeleton organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of protein modification process |
| phosphorylation |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| ATP binding |
| regulation of apoptotic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Talazoparib 0.006μM R06 exp299 | -1.74 |
| Rapamycin 1μM R00 exp29 | 1.8 |
| S-DABN 8μM R03 exp112 | 1.83 |
| HMS-I2 1μM R06 exp286 | 1.92 |
| Nifurtimox 1μM R03 exp141 | 1.94 |
| MS023 2μM R03 exp134 | 1.95 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14684
- Expression level (log2 read counts): 6.83
Expression Distribution
SLK Expression in NALM6 Cells: 6.83
