SMPD3
Gene Information
- Official Symbol: SMPD3
- Official Name: sphingomyelin phosphodiesterase 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 55512
- UniProt: Q9NY59
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization. {ECO:0000269|PubMed:10823942, ECO:0000269|PubMed:14741383, ECO:0000269|PubMed:15051724}.
Pfam Domains GO Terms
Pfam Domains
| Exo endo phos |
GO Terms
| polysaccharide transport |
| neutral sphingomyelin phosphodiesterase activity |
| polysaccharide localization |
| cellular response to redox state |
| negative regulation of hyaluronan biosynthetic process |
| cellular response to magnesium ion |
| dentinogenesis |
| sphingomyelin catabolic process |
| sphingomyelin phosphodiesterase activity |
| regulation of hyaluronan biosynthetic process |
| G1 to G0 transition |
| positive regulation of sphingolipid biosynthetic process |
| cellular response to oxidised low-density lipoprotein particle stimulus |
| positive regulation of ceramide biosynthetic process |
| sphingolipid mediated signaling pathway |
| sphingomyelin metabolic process |
| response to redox state |
| positive regulation of exosomal secretion |
| regulation of membrane lipid metabolic process |
| regulation of ceramide biosynthetic process |
| regulation of sphingolipid biosynthetic process |
| phospholipase activity |
| regulation of exosomal secretion |
| extracellular matrix assembly |
| response to magnesium ion |
| chondrocyte development involved in endochondral bone morphogenesis |
| response to lipoprotein particle |
| replacement ossification |
| endochondral ossification |
| Golgi cis cisterna |
| cellular response to lipoprotein particle stimulus |
| chondrocyte differentiation involved in endochondral bone morphogenesis |
| sphingolipid catabolic process |
| platelet-derived growth factor receptor signaling pathway |
| membrane lipid catabolic process |
| phospholipid catabolic process |
| regulation of polysaccharide biosynthetic process |
| protein kinase B signaling |
| lung alveolus development |
| chondrocyte development |
| regulation of polysaccharide metabolic process |
| bone growth |
| cartilage development involved in endochondral bone morphogenesis |
| negative regulation of carbohydrate metabolic process |
| bone mineralization |
| positive regulation of mitotic nuclear division |
| peptide hormone secretion |
| glycosphingolipid metabolic process |
| collagen metabolic process |
| positive regulation of nuclear division |
| regulation of cartilage development |
| cellular response to hydrogen peroxide |
| endochondral bone morphogenesis |
| hormone secretion |
| carbohydrate transport |
| positive regulation of lipid biosynthetic process |
| hormone transport |
| chondrocyte differentiation |
| odontogenesis of dentin-containing tooth |
| multicellular organism growth |
| ceramide metabolic process |
| positive regulation of smooth muscle cell proliferation |
| hematopoietic progenitor cell differentiation |
| positive regulation of exocytosis |
| BMP signaling pathway |
| negative regulation of small molecule metabolic process |
| biomineralization |
| biomineral tissue development |
| regulation of carbohydrate biosynthetic process |
| organ growth |
| response to BMP |
| cellular response to BMP stimulus |
| glycolipid metabolic process |
| liposaccharide metabolic process |
| DNA biosynthetic process |
| bone morphogenesis |
| cellular response to antibiotic |
| response to hydrogen peroxide |
| odontogenesis |
| organophosphate catabolic process |
| cellular response to reactive oxygen species |
| regulation of smooth muscle cell proliferation |
| positive regulation of lipid metabolic process |
| mitotic nuclear division |
| positive regulation of cellular amide metabolic process |
| positive regulation of mitotic cell cycle |
| sphingolipid metabolic process |
| regulation of mitotic nuclear division |
| lung development |
| signal release |
| cartilage development |
| respiratory tube development |
| peptide secretion |
| regulation of lipid biosynthetic process |
| regulation of nuclear division |
| cellular response to metal ion |
| ammonium ion metabolic process |
| response to reactive oxygen species |
| cellular lipid catabolic process |
| respiratory system development |
| regulation of leukocyte migration |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| bone development |
| membrane lipid metabolic process |
| regulation of carbohydrate metabolic process |
| cellular response to toxic substance |
| cellular response to inorganic substance |
| regulation of exocytosis |
| connective tissue development |
| skeletal system morphogenesis |
| cellular response to tumor necrosis factor |
| cellular response to oxidative stress |
| ossification |
| response to tumor necrosis factor |
| nuclear division |
| positive regulation of cell cycle process |
| lipid catabolic process |
| response to antibiotic |
| organelle fission |
| cellular response to peptide |
| protein homooligomerization |
| extracellular matrix organization |
| response to metal ion |
| phospholipid metabolic process |
| positive regulation of cell cycle |
| response to oxidative stress |
| extracellular structure organization |
| developmental growth |
| growth |
| regulation of lipid metabolic process |
| positive regulation of secretion by cell |
| regulation of cellular amide metabolic process |
| cellular response to drug |
| regulation of small molecule metabolic process |
| positive regulation of secretion |
| response to peptide |
| skeletal system development |
| cellular response to growth factor stimulus |
| response to toxic substance |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| protein complex oligomerization |
| positive regulation of cellular component biogenesis |
| response to growth factor |
| regulation of hormone levels |
| response to inorganic substance |
| regulation of vesicle-mediated transport |
| hemopoiesis |
| mitotic cell cycle process |
| cellular response to organonitrogen compound |
| hematopoietic or lymphoid organ development |
| Golgi membrane |
| positive regulation of organelle organization |
| regulation of mitotic cell cycle |
| immune system development |
| cellular response to nitrogen compound |
| mitotic cell cycle |
| enzyme linked receptor protein signaling pathway |
| DNA metabolic process |
| regulation of secretion by cell |
| regulation of cell cycle process |
| cellular amide metabolic process |
| regulation of secretion |
| tube development |
| regulation of cell migration |
| organophosphate metabolic process |
| anatomical structure formation involved in morphogenesis |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| cellular lipid metabolic process |
| animal organ morphogenesis |
| regulation of cellular component biogenesis |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| cell cycle process |
| response to organonitrogen compound |
| secretion by cell |
| cellular response to cytokine stimulus |
| response to drug |
| carbohydrate derivative metabolic process |
| export from cell |
| cellular response to oxygen-containing compound |
| organonitrogen compound catabolic process |
| response to nitrogen compound |
| nucleobase-containing compound biosynthetic process |
| response to cytokine |
| cell-cell signaling |
| secretion |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| regulation of organelle organization |
| organic cyclic compound biosynthetic process |
| cell cycle |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| peptide transport |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| amide transport |
| regulation of phosphorylation |
| regulation of cell population proliferation |
| cellular nitrogen compound biosynthetic process |
| cell development |
| regulation of immune system process |
| intracellular signal transduction |
| cellular response to stress |
| cellular macromolecule biosynthetic process |
| tissue development |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| regulation of protein modification process |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| regulation of transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| BI-6727 0.001μM R01 exp42 | -1.98 |
| GSK461364A 0.1μM R03 exp126 | -1.96 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3528
- Expression level (log2 read counts): 1.46
Expression Distribution
SMPD3 Expression in NALM6 Cells: 1.46
