Pfam Domains GO Terms
| PX |
| Sorting nexin |
| Vps5 |
| leptin receptor binding |
| retromer, tubulation complex |
| lamellipodium morphogenesis |
| transferrin receptor binding |
| early endosome to Golgi transport |
| retromer complex |
| insulin receptor binding |
| epidermal growth factor receptor binding |
| lamellipodium organization |
| phosphatidylinositol binding |
| retrograde transport, endosome to Golgi |
| cytosolic transport |
| early endosome membrane |
| lamellipodium |
| endosome membrane |
| endosomal transport |
| lysosome |
| endosome |
| cadherin binding |
| Golgi vesicle transport |
| plasma membrane bounded cell projection morphogenesis |
| protein heterodimerization activity |
| cell projection morphogenesis |
| cell part morphogenesis |
| protein complex oligomerization |
| endocytosis |
| protein-containing complex |
| import into cell |
| cell morphogenesis |
| cellular component morphogenesis |
| protein homodimerization activity |
| intracellular protein transport |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| protein transport |
| intracellular transport |
| peptide transport |
| protein-containing complex assembly |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| vesicle-mediated transport |
| membrane |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| CAY10603 0.55μM R08 exp467 | 1.74 |
| Cannabidiol 20μM R08 exp466 | 1.81 |
| CyclicAMP 200μM R08 exp475 | 1.86 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution