SP100
Gene Information
- Official Symbol: SP100
- Official Name: SP100 nuclear antigen
- Aliases and Previous Symbols: N/A
- Entrez ID: 6672
- UniProt: P23497
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene; one of which encodes a high-mobility group protein. [provided by RefSeq, Aug 2011].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| HMG box |
| Sp100 |
| Bromodomain |
| SAND |
| PHD |
GO Terms
| regulation of Fas signaling pathway |
| negative regulation of protein export from nucleus |
| chromo shadow domain binding |
| Mre11 complex |
| DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator |
| DNA damage response, signal transduction resulting in transcription |
| negative regulation of nucleocytoplasmic transport |
| maintenance of protein location in nucleus |
| regulation of protein export from nucleus |
| maintenance of protein localization in organelle |
| negative regulation of intracellular protein transport |
| negative regulation of endothelial cell migration |
| negative regulation of DNA binding |
| regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| negative regulation of intracellular transport |
| cellular response to type I interferon |
| negative regulation of epithelial cell migration |
| type I interferon signaling pathway |
| response to type I interferon |
| interferon-gamma-mediated signaling pathway |
| maintenance of protein location in cell |
| DNA damage response, signal transduction by p53 class mediator |
| kinase binding |
| maintenance of location in cell |
| telomere maintenance |
| PML body |
| telomere organization |
| signal transduction in response to DNA damage |
| regulation of nucleocytoplasmic transport |
| maintenance of protein location |
| nuclear chromosome, telomeric region |
| negative regulation of cellular protein localization |
| signal transduction by p53 class mediator |
| regulation of DNA binding |
| regulation of extrinsic apoptotic signaling pathway |
| regulation of endothelial cell migration |
| protein dimerization activity |
| negative regulation of DNA-binding transcription factor activity |
| cellular response to interferon-gamma |
| protein localization to nucleus |
| maintenance of location |
| negative regulation of binding |
| negative regulation of protein transport |
| response to interferon-gamma |
| negative regulation of establishment of protein localization |
| regulation of epithelial cell migration |
| regulation of intracellular protein transport |
| protein domain specific binding |
| negative regulation of cell migration |
| negative regulation of cell motility |
| nuclear body |
| regulation of angiogenesis |
| negative regulation of cellular component movement |
| regulation of vasculature development |
| negative regulation of locomotion |
| anatomical structure homeostasis |
| regulation of intracellular transport |
| regulation of binding |
| regulation of apoptotic signaling pathway |
| regulation of DNA-binding transcription factor activity |
| negative regulation of transport |
| regulation of cellular protein localization |
| cytokine-mediated signaling pathway |
| viral process |
| regulation of protein transport |
| protein localization to organelle |
| regulation of peptide transport |
| DNA metabolic process |
| regulation of establishment of protein localization |
| innate immune response |
| cellular response to DNA damage stimulus |
| symbiotic process |
| interspecies interaction between organisms |
| regulation of cell migration |
| negative regulation of transcription by RNA polymerase II |
| regulation of cell motility |
| regulation of cellular localization |
| defense response to other organism |
| regulation of locomotion |
| regulation of cellular component movement |
| cellular response to cytokine stimulus |
| regulation of protein localization |
| regulation of anatomical structure morphogenesis |
| chromosome organization |
| response to cytokine |
| negative regulation of molecular function |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| defense response |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| cellular protein localization |
| cellular macromolecule localization |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| regulation of transport |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| ABT-702 0.1μM R06 exp260 | -1.86 |
| Calcipotriol 5μM R08 exp464 | 1.81 |
| PU-H71 1μM R08 exp515 | 1.93 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15007
- Expression level (log2 read counts): 6.4
Expression Distribution
SP100 Expression in NALM6 Cells: 6.4
