SP7
Gene Information
- Official Symbol: SP7
- Official Name: Sp7 transcription factor
- Aliases and Previous Symbols: N/A
- Entrez ID: 121340
- UniProt: Q8TDD2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.[provided by RefSeq, Jul 2010].
- UniProt Summary: Transcriptional activator essential for osteoblast differentiation (PubMed:23457570). Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity). {ECO:0000250|UniProtKB:Q8VI67, ECO:0000269|PubMed:23457570}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 3385
- Expression level (log2 read counts): -5.6
SP7 Expression in NALM6 Cells: -5.6
