SPRED1
Gene Information
- Official Symbol: SPRED1
- Official Name: sprouty related EVH1 domain containing 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 161742
- UniProt: Q7Z699
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008].
- UniProt Summary: Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| WH1 |
| Sprouty |
GO Terms
| vasculogenesis involved in coronary vascular morphogenesis |
| stem cell factor receptor binding |
| protein serine/threonine kinase inhibitor activity |
| positive regulation of DNA damage response, signal transduction by p53 class mediator |
| negative regulation of cell migration involved in sprouting angiogenesis |
| coronary vasculature morphogenesis |
| negative regulation of peptidyl-threonine phosphorylation |
| positive regulation of signal transduction by p53 class mediator |
| negative regulation of sprouting angiogenesis |
| inactivation of MAPK activity |
| negative regulation of blood vessel endothelial cell migration |
| regulation of DNA damage response, signal transduction by p53 class mediator |
| regulation of cell migration involved in sprouting angiogenesis |
| regulation of protein deacetylation |
| regulation of peptidyl-threonine phosphorylation |
| coronary vasculature development |
| negative regulation of endothelial cell migration |
| phosphatase binding |
| negative regulation of ERK1 and ERK2 cascade |
| negative regulation of epithelial cell migration |
| vasculogenesis |
| regulation of sprouting angiogenesis |
| caveola |
| negative regulation of MAP kinase activity |
| fibroblast growth factor receptor signaling pathway |
| regulation of blood vessel endothelial cell migration |
| positive regulation of response to DNA damage stimulus |
| negative regulation of angiogenesis |
| negative regulation of phosphatase activity |
| negative regulation of blood vessel morphogenesis |
| cellular response to fibroblast growth factor stimulus |
| negative regulation of dephosphorylation |
| negative regulation of vasculature development |
| response to fibroblast growth factor |
| negative regulation of protein serine/threonine kinase activity |
| regulation of endothelial cell migration |
| negative regulation of MAPK cascade |
| regulation of phosphatase activity |
| regulation of signal transduction by p53 class mediator |
| regulation of dephosphorylation |
| regulation of response to DNA damage stimulus |
| regulation of epithelial cell migration |
| negative regulation of protein kinase activity |
| negative regulation of kinase activity |
| cytoplasmic vesicle |
| negative regulation of cell migration |
| negative regulation of cell motility |
| negative regulation of transferase activity |
| regulation of angiogenesis |
| regulation of ERK1 and ERK2 cascade |
| negative regulation of cellular component movement |
| regulation of vasculature development |
| negative regulation of locomotion |
| regulation of MAP kinase activity |
| MAPK cascade |
| signal transduction by protein phosphorylation |
| negative regulation of protein phosphorylation |
| blood vessel morphogenesis |
| negative regulation of phosphorylation |
| negative regulation of hydrolase activity |
| protein kinase binding |
| blood vessel development |
| cellular response to growth factor stimulus |
| negative regulation of intracellular signal transduction |
| vasculature development |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| regulation of protein serine/threonine kinase activity |
| cardiovascular system development |
| heart development |
| response to growth factor |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of protein modification process |
| tube morphogenesis |
| enzyme linked receptor protein signaling pathway |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| tube development |
| regulation of cell migration |
| circulatory system development |
| regulation of kinase activity |
| regulation of cell motility |
| negative regulation of developmental process |
| protein phosphorylation |
| regulation of transferase activity |
| regulation of locomotion |
| regulation of cellular component movement |
| positive regulation of intracellular signal transduction |
| negative regulation of cellular protein metabolic process |
| regulation of anatomical structure morphogenesis |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| negative regulation of multicellular organismal process |
| cellular response to endogenous stimulus |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| phosphorylation |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| regulation of phosphorylation |
| negative regulation of response to stimulus |
| positive regulation of signal transduction |
| intracellular signal transduction |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Q15 2.7μM R02 exp79 | -1.71 |
| Thimerosal 0.85μM R08 exp529 | 1.72 |
| Nifurtimox 1μM R03 exp141 | 1.73 |
| BI-2536 0.001μM R01 exp41 | 1.81 |
| Ibrutinib 10μM R08 exp442 | 1.81 |
| 35°C R06 exp302 | 1.92 |
| A-196 10μM R03 exp114 | 1.99 |
| QNZ 0.01μM R08 exp439 | 2.07 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18767
- Expression level (log2 read counts): 5.43
Expression Distribution
SPRED1 Expression in NALM6 Cells: 5.43
