STAT1
Gene Information
- Official Symbol: STAT1
- Official Name: signal transducer and activator of transcription 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6772
- UniProt: P42224
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| SH2 |
| STAT bind |
| STAT1 TAZ2bind |
| STAT alpha |
| STAT int |
GO Terms
| negative regulation by virus of viral protein levels in host cell |
| negative regulation of metanephric nephron tubule epithelial cell differentiation |
| negative regulation of nephron tubule epithelial cell differentiation |
| negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis |
| metanephric mesenchymal cell proliferation involved in metanephros development |
| kidney mesenchymal cell proliferation |
| negative regulation of epithelial cell differentiation involved in kidney development |
| metanephric mesenchymal cell differentiation |
| regulation of metanephric nephron tubule epithelial cell differentiation |
| cell proliferation involved in metanephros development |
| regulation by virus of viral protein levels in host cell |
| CCR5 chemokine receptor binding |
| foam cell differentiation |
| macrophage derived foam cell differentiation |
| regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis |
| mesenchymal cell differentiation involved in kidney development |
| cellular response to interleukin-21 |
| mesenchymal cell differentiation involved in renal system development |
| interleukin-21-mediated signaling pathway |
| response to interleukin-21 |
| interleukin-9-mediated signaling pathway |
| cellular response to interleukin-9 |
| negative regulation of metanephros development |
| response to interleukin-9 |
| cell proliferation involved in kidney development |
| interleukin-35-mediated signaling pathway |
| interleukin-27-mediated signaling pathway |
| regulation of nephron tubule epithelial cell differentiation |
| metanephric mesenchyme development |
| positive regulation of nitric-oxide synthase biosynthetic process |
| negative regulation of kidney development |
| mesenchymal cell proliferation |
| negative regulation of morphogenesis of an epithelium |
| interleukin-6-mediated signaling pathway |
| cell differentiation involved in metanephros development |
| kidney mesenchyme development |
| positive regulation of transcription of Notch receptor target |
| regulation of epithelial cell differentiation involved in kidney development |
| regulation of nitric-oxide synthase biosynthetic process |
| cellular response to interferon-beta |
| ubiquitin-like protein ligase binding |
| positive regulation of interferon-alpha production |
| regulation of metanephros development |
| positive regulation of mesenchymal cell proliferation |
| regulation of response to interferon-gamma |
| regulation of interferon-gamma-mediated signaling pathway |
| positive regulation of defense response to virus by host |
| nuclear hormone receptor binding |
| response to interferon-beta |
| regulation of interferon-alpha production |
| histone acetyltransferase binding |
| positive regulation of erythrocyte differentiation |
| tumor necrosis factor receptor binding |
| protein phosphatase 2A binding |
| cellular response to interleukin-6 |
| regulation of mesenchymal cell proliferation |
| RNA polymerase II core promoter sequence-specific DNA binding |
| negative regulation of animal organ morphogenesis |
| response to interleukin-6 |
| regulation of defense response to virus by host |
| negative regulation of endothelial cell proliferation |
| receptor signaling pathway via JAK-STAT |
| repressing transcription factor binding |
| receptor signaling pathway via STAT |
| cell differentiation involved in kidney development |
| negative regulation of epithelial cell differentiation |
| negative regulation of I-kappaB kinase/NF-kappaB signaling |
| regulation of erythrocyte differentiation |
| promoter-specific chromatin binding |
| regulation of kidney development |
| endothelial cell migration |
| type I interferon signaling pathway |
| cellular response to type I interferon |
| response to type I interferon |
| interferon-gamma-mediated signaling pathway |
| regulation of defense response to virus |
| positive regulation of type I interferon production |
| renal tubule development |
| epithelial cell migration |
| metanephros development |
| positive regulation of smooth muscle cell proliferation |
| epithelium migration |
| positive regulation of myeloid cell differentiation |
| tissue migration |
| negative regulation of viral process |
| response to cAMP |
| negative regulation of angiogenesis |
| double-stranded DNA binding |
| negative regulation of blood vessel morphogenesis |
| negative regulation of vasculature development |
| response to hydrogen peroxide |
| tumor necrosis factor-mediated signaling pathway |
| negative regulation of epithelial cell proliferation |
| Notch signaling pathway |
| regulation of type I interferon production |
| regulation of endothelial cell proliferation |
| histone binding |
| regulation of smooth muscle cell proliferation |
| response to organophosphorus |
| regulation of epithelial cell differentiation |
| response to purine-containing compound |
| mesenchymal cell differentiation |
| cellular response to interferon-gamma |
| cellular response to insulin stimulus |
| regulation of cytokine-mediated signaling pathway |
| ameboidal-type cell migration |
| regulation of response to cytokine stimulus |
| regulation of morphogenesis of an epithelium |
| response to interferon-gamma |
| positive regulation of hemopoiesis |
| defense response to virus |
| response to reactive oxygen species |
| regulation of viral process |
| response to mechanical stimulus |
| response to nutrient |
| negative regulation of multi-organism process |
| regulation of symbiosis, encompassing mutualism through parasitism |
| mesenchyme development |
| regulation of myeloid cell differentiation |
| response to insulin |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| nuclear chromatin |
| cellular response to tumor necrosis factor |
| regulation of animal organ morphogenesis |
| response to tumor necrosis factor |
| cellular response to peptide hormone stimulus |
| kidney development |
| response to virus |
| renal system development |
| regulation of angiogenesis |
| axon |
| response to antibiotic |
| cadherin binding |
| urogenital system development |
| regulation of vasculature development |
| cellular response to peptide |
| regulation of epithelial cell proliferation |
| enzyme binding |
| response to oxidative stress |
| blood circulation |
| response to peptide hormone |
| circulatory system process |
| dendrite |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| positive regulation of cytokine production |
| regulation of hemopoiesis |
| regulation of innate immune response |
| regulation of immune effector process |
| response to peptide |
| response to nutrient levels |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| negative regulation of intracellular signal transduction |
| response to toxic substance |
| regulation of response to biotic stimulus |
| response to extracellular stimulus |
| response to inorganic substance |
| cellular response to organic cyclic compound |
| cell population proliferation |
| protein-containing complex |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| cellular response to nitrogen compound |
| cytokine-mediated signaling pathway |
| DNA-binding transcription factor activity |
| negative regulation of cell population proliferation |
| regulation of cytokine production |
| perinuclear region of cytoplasm |
| viral process |
| negative regulation of cell differentiation |
| regulation of defense response |
| innate immune response |
| regulation of multi-organism process |
| symbiotic process |
| interspecies interaction between organisms |
| tube development |
| nucleolus |
| negative regulation of transcription by RNA polymerase II |
| protein homodimerization activity |
| response to hormone |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| negative regulation of developmental process |
| defense response to other organism |
| cell migration |
| positive regulation of cell differentiation |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| response to drug |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| identical protein binding |
| localization of cell |
| cell motility |
| response to nitrogen compound |
| immune effector process |
| regulation of response to external stimulus |
| response to cytokine |
| chemical homeostasis |
| epithelium development |
| regulation of immune response |
| positive regulation of immune system process |
| response to abiotic stimulus |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| regulation of immune system process |
| regulation of cell death |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of cell differentiation |
| regulation of intracellular signal transduction |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| HMS-I1 1μM R01 exp46 | 1.8 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18782
- Expression level (log2 read counts): 5.76
Expression Distribution
STAT1 Expression in NALM6 Cells: 5.76
