Pfam Domains GO Terms
| Syntaxin |
| SNARE |
| cornified envelope assembly |
| presynaptic active zone membrane |
| synaptic vesicle fusion to presynaptic active zone membrane |
| vesicle fusion to plasma membrane |
| response to hydroperoxide |
| ectoderm development |
| acrosome reaction |
| SNAP receptor activity |
| membrane assembly |
| membrane biogenesis |
| SNARE complex |
| calcium-dependent protein binding |
| vesicle docking |
| synaptic vesicle exocytosis |
| SNARE binding |
| exocytic process |
| vesicle fusion |
| presynaptic membrane |
| endomembrane system |
| organelle membrane fusion |
| plasma membrane organization |
| organelle fusion |
| neurotransmitter secretion |
| signal release from synapse |
| synaptic vesicle cycle |
| synaptic vesicle |
| vesicle-mediated transport in synapse |
| membrane fusion |
| single fertilization |
| protein dimerization activity |
| signal release |
| organelle localization by membrane tethering |
| fertilization |
| membrane docking |
| neurotransmitter transport |
| lamellipodium |
| basolateral plasma membrane |
| vesicle organization |
| regulation of neurotransmitter levels |
| response to oxidative stress |
| endomembrane system organization |
| anterograde trans-synaptic signaling |
| chemical synaptic transmission |
| trans-synaptic signaling |
| synaptic signaling |
| protein complex oligomerization |
| organelle localization |
| intracellular membrane-bounded organelle |
| regulated exocytosis |
| exocytosis |
| sexual reproduction |
| membrane organization |
| animal organ morphogenesis |
| multi-organism reproductive process |
| intracellular protein transport |
| secretion by cell |
| export from cell |
| cell-cell signaling |
| secretion |
| reproductive process |
| reproduction |
| protein transport |
| intracellular transport |
| peptide transport |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| extracellular space |
| establishment of protein localization |
| tissue development |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| vesicle-mediated transport |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| Benzoate 10000μM R08 exp455 | -1.88 |
| Pyrazinamide 100μM R08 exp516 | -1.72 |
| Trientine 500μM R08 exp534 | 1.83 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution