SULF2
Gene Information
- Official Symbol: SULF2
- Official Name: sulfatase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 55959
- UniProt: Q8IWU5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
Pfam Domains GO Terms
Pfam Domains
| Sulfatase |
| DUF3740 |
GO Terms
| esophagus smooth muscle contraction |
| N-acetylglucosamine-6-sulfatase activity |
| gastro-intestinal system smooth muscle contraction |
| glial cell-derived neurotrophic factor receptor signaling pathway |
| glomerular basement membrane development |
| glomerular filtration |
| renal filtration |
| arylsulfatase activity |
| regulation of hepatocyte proliferation |
| negative regulation of fibroblast growth factor receptor signaling pathway |
| glycosaminoglycan binding |
| innervation |
| positive regulation of vascular endothelial growth factor production |
| regulation of fibroblast growth factor receptor signaling pathway |
| liver regeneration |
| regulation of vascular endothelial growth factor production |
| heparan sulfate proteoglycan metabolic process |
| Golgi stack |
| chondrocyte development |
| glomerulus development |
| smooth muscle contraction |
| animal organ regeneration |
| nerve development |
| chondrocyte differentiation |
| proteoglycan metabolic process |
| renal system process |
| nephron development |
| liver development |
| embryonic skeletal system development |
| hepaticobiliary system development |
| positive regulation of canonical Wnt signaling pathway |
| negative regulation of cellular response to growth factor stimulus |
| regeneration |
| cartilage development |
| positive regulation of Wnt signaling pathway |
| bone development |
| connective tissue development |
| muscle contraction |
| regulation of animal organ morphogenesis |
| kidney development |
| regulation of cellular response to growth factor stimulus |
| regulation of canonical Wnt signaling pathway |
| renal system development |
| muscle system process |
| urogenital system development |
| regulation of epithelial cell proliferation |
| extracellular matrix organization |
| regulation of Wnt signaling pathway |
| extracellular structure organization |
| glycoprotein metabolic process |
| gland development |
| positive regulation of cytokine production |
| skeletal system development |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| response to wounding |
| cell surface |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| regulation of cytokine production |
| enzyme linked receptor protein signaling pathway |
| calcium ion binding |
| embryo development |
| endoplasmic reticulum |
| carbohydrate derivative metabolic process |
| regulation of anatomical structure morphogenesis |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| extracellular space |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| cell development |
| positive regulation of signal transduction |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of cell communication |
| positive regulation of signaling |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Doxorubicin 0.02μM R08 exp478 | -1.79 |
| Ibrutinib 1μM R07 exp372 | -1.78 |
| Wortmannin 5μM R00 exp38 | 1.8 |
| Radicicol 0.16μM R05 exp242 | 1.9 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6104
- Expression level (log2 read counts): 1.31
Expression Distribution
SULF2 Expression in NALM6 Cells: 1.31
