TEX15
Gene Information
- Official Symbol: TEX15
- Official Name: testis expressed 15, meiosis and synapsis associated
- Aliases and Previous Symbols: N/A
- Entrez ID: 56154
- UniProt: Q9BXT5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein that is required for DNA double-strand break repair, chromosome synapsis, and meiotic recombination in spermatocytes. Male mice with a knockout of the orthologous gene are viable but sterile. Loss-of-function mutations in the orthologous mouse gene cause early meiotic arrest in spermatocytes, before the mid-pachytene stage. Naturally occurring mutations in this gene are associated with nonobstructive azoospermia. [provided by RefSeq, Apr 2017].
- UniProt Summary: Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair. {ECO:0000250|UniProtKB:F8VPN2}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 12507
- Expression level (log2 read counts): -3.59
TEX15 Expression in NALM6 Cells: -3.59
