TFAP2E
Gene Information
- Official Symbol: TFAP2E
- Official Name: transcription factor AP-2 epsilon
- Aliases and Previous Symbols: N/A
- Entrez ID: 339488
- UniProt: Q6VUC0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity). {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 6686
- Expression level (log2 read counts): 0.22
TFAP2E Expression in NALM6 Cells: 0.22
