TGFB3
Gene Information
- Official Symbol: TGFB3
- Official Name: transforming growth factor beta 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 7043
- UniProt: P10600
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Aug 2016].
- UniProt Summary: Involved in embryogenesis and cell differentiation.
Pfam Domains GO Terms
Pfam Domains
| TGFb propeptide |
| TGF beta |
GO Terms
| detection of hypoxia |
| detection of oxygen |
| regulation of tight junction disassembly |
| uterine wall breakdown |
| positive regulation of tight junction disassembly |
| type III transforming growth factor beta receptor binding |
| frontal suture morphogenesis |
| ossification involved in bone remodeling |
| negative regulation of macrophage cytokine production |
| embryonic neurocranium morphogenesis |
| type II transforming growth factor beta receptor binding |
| regulation of epithelial to mesenchymal transition involved in endocardial cushion formation |
| cranial suture morphogenesis |
| type I transforming growth factor beta receptor binding |
| regulation of cardiac epithelial to mesenchymal transition |
| positive regulation of SMAD protein signal transduction |
| response to laminar fluid shear stress |
| regulation of macrophage cytokine production |
| negative regulation of vascular smooth muscle cell proliferation |
| craniofacial suture morphogenesis |
| transforming growth factor beta binding |
| regulation of SMAD protein signal transduction |
| secondary palate development |
| negative regulation of cytokine production involved in immune response |
| positive regulation of collagen biosynthetic process |
| positive regulation of collagen metabolic process |
| salivary gland morphogenesis |
| positive regulation of filopodium assembly |
| salivary gland development |
| face morphogenesis |
| response to fluid shear stress |
| negative regulation of production of molecular mediator of immune response |
| regulation of collagen biosynthetic process |
| head morphogenesis |
| positive regulation of bone mineralization |
| regulation of heart morphogenesis |
| regulation of collagen metabolic process |
| lung alveolus development |
| transforming growth factor beta receptor binding |
| ovulation cycle process |
| T-tubule |
| exocrine system development |
| negative regulation of smooth muscle cell proliferation |
| regulation of filopodium assembly |
| embryonic cranial skeleton morphogenesis |
| response to progesterone |
| body morphogenesis |
| bone remodeling |
| positive regulation of biomineral tissue development |
| positive regulation of biomineralization |
| positive regulation of epithelial to mesenchymal transition |
| positive regulation of pathway-restricted SMAD protein phosphorylation |
| face development |
| regulation of vascular smooth muscle cell proliferation |
| positive regulation of stress fiber assembly |
| SMAD protein signal transduction |
| regulation of pathway-restricted SMAD protein phosphorylation |
| positive regulation of actin filament bundle assembly |
| cranial skeletal system development |
| ovulation cycle |
| platelet alpha granule lumen |
| negative regulation of transforming growth factor beta receptor signaling pathway |
| regulation of bone mineralization |
| negative regulation of cellular response to transforming growth factor beta stimulus |
| response to estrogen |
| regulation of stress fiber assembly |
| regulation of epithelial to mesenchymal transition |
| regulation of cytokine production involved in immune response |
| positive regulation of ossification |
| positive regulation of cell division |
| regulation of actomyosin structure organization |
| roof of mouth development |
| regulation of actin filament bundle assembly |
| regulation of biomineral tissue development |
| regulation of biomineralization |
| embryonic skeletal system morphogenesis |
| gland morphogenesis |
| tissue remodeling |
| positive regulation of plasma membrane bounded cell projection assembly |
| transforming growth factor beta receptor signaling pathway |
| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| regulation of transforming growth factor beta receptor signaling pathway |
| bone morphogenesis |
| regulation of cellular response to transforming growth factor beta stimulus |
| negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| odontogenesis |
| negative regulation of immune effector process |
| embryonic skeletal system development |
| mammary gland development |
| platelet degranulation |
| digestive tract development |
| regulation of smooth muscle cell proliferation |
| cell-cell junction organization |
| regulation of production of molecular mediator of immune response |
| digestive system development |
| negative regulation of neuron apoptotic process |
| negative regulation of cellular response to growth factor stimulus |
| negative regulation of immune response |
| activation of MAPK activity |
| cellular response to transforming growth factor beta stimulus |
| response to transforming growth factor beta |
| growth factor activity |
| regulation of cell division |
| lung development |
| respiratory tube development |
| cytokine activity |
| female pregnancy |
| regulation of ossification |
| inner ear development |
| response to ketone |
| respiratory system development |
| positive regulation of supramolecular fiber organization |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| bone development |
| regulation of plasma membrane bounded cell projection assembly |
| regulation of cell projection assembly |
| regulation of neuron apoptotic process |
| negative regulation of neuron death |
| multi-multicellular organism process |
| cell junction organization |
| positive regulation of cytoskeleton organization |
| ear development |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| skeletal system morphogenesis |
| regulation of animal organ morphogenesis |
| regulation of actin filament organization |
| positive regulation of MAP kinase activity |
| ossification |
| positive regulation of protein secretion |
| regulation of cellular response to growth factor stimulus |
| negative regulation of cytokine production |
| rhythmic process |
| aging |
| embryonic organ morphogenesis |
| positive regulation of peptide secretion |
| regulation of neuron death |
| response to steroid hormone |
| activation of protein kinase activity |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| response to hypoxia |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| response to decreased oxygen levels |
| collagen-containing extracellular matrix |
| neuronal cell body |
| in utero embryonic development |
| response to oxygen levels |
| positive regulation of cell projection organization |
| regulation of actin filament-based process |
| positive regulation of secretion by cell |
| gland development |
| positive regulation of protein transport |
| embryonic organ development |
| positive regulation of secretion |
| negative regulation of immune system process |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| regulation of immune effector process |
| wound healing |
| protein heterodimerization activity |
| skeletal system development |
| regulation of peptide secretion |
| cellular response to growth factor stimulus |
| regulation of protein serine/threonine kinase activity |
| positive regulation of cellular component biogenesis |
| detection of chemical stimulus |
| response to growth factor |
| positive regulation of protein kinase activity |
| regulation of cytoskeleton organization |
| positive regulation of MAPK cascade |
| sensory organ development |
| embryonic morphogenesis |
| response to wounding |
| positive regulation of kinase activity |
| cell surface |
| positive regulation of organelle organization |
| chordate embryonic development |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| embryo development ending in birth or egg hatching |
| positive regulation of transferase activity |
| negative regulation of cell population proliferation |
| intracellular membrane-bounded organelle |
| detection of stimulus |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cytokine production |
| positive regulation of cell death |
| regulated exocytosis |
| regulation of protein transport |
| regulation of cell projection organization |
| enzyme linked receptor protein signaling pathway |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| head development |
| exocytosis |
| regulation of protein kinase activity |
| regulation of secretion |
| multicellular organismal reproductive process |
| multicellular organism reproduction |
| tube development |
| response to lipid |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| response to hormone |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| animal organ morphogenesis |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| embryo development |
| regulation of transferase activity |
| positive regulation of transport |
| negative regulation of cell death |
| multi-organism reproductive process |
| secretion by cell |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| response to drug |
| regulation of protein localization |
| export from cell |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| identical protein binding |
| secretion |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| regulation of immune response |
| response to abiotic stimulus |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| regulation of organelle organization |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| vesicle-mediated transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11174
- Expression level (log2 read counts): 1.08
Expression Distribution
TGFB3 Expression in NALM6 Cells: 1.08
