TMEM106A
Gene Information
- Official Symbol: TMEM106A
- Official Name: transmembrane protein 106A
- Aliases and Previous Symbols: N/A
- Entrez ID: 113277
- UniProt: Q96A25
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: N/A
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| DUF1356 |
GO Terms
| CD80 biosynthetic process |
| CD86 biosynthetic process |
| tumor necrosis factor secretion |
| interleukin-6 secretion |
| tumor necrosis factor production |
| tumor necrosis factor superfamily cytokine production |
| interleukin-1 beta secretion |
| positive regulation of MHC class II biosynthetic process |
| interleukin-1 secretion |
| interleukin-6 production |
| regulation of MHC class II biosynthetic process |
| interleukin-1 beta production |
| interleukin-1 production |
| positive regulation of nitric oxide metabolic process |
| cytokine secretion |
| macrophage activation |
| positive regulation of reactive oxygen species metabolic process |
| cytokine production |
| protein secretion |
| establishment of protein localization to extracellular region |
| protein localization to extracellular region |
| peptide secretion |
| regulation of reactive oxygen species metabolic process |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| glycoprotein biosynthetic process |
| regulation of neurotransmitter levels |
| glycoprotein metabolic process |
| positive regulation of MAPK cascade |
| myeloid leukocyte activation |
| carbohydrate derivative biosynthetic process |
| regulation of MAPK cascade |
| molecular function |
| innate immune response |
| leukocyte activation |
| defense response to other organism |
| secretion by cell |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| carbohydrate derivative metabolic process |
| export from cell |
| positive regulation of phosphorylation |
| cell activation |
| secretion |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of protein modification process |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| organonitrogen compound biosynthetic process |
| regulation of protein phosphorylation |
| protein transport |
| peptide transport |
| amide transport |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| positive regulation of signal transduction |
| positive regulation of protein metabolic process |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| nitrogen compound transport |
| immune response |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| MSC2530818 10μM R07 exp379 | 1.7 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7578
- Expression level (log2 read counts): 3.68
Expression Distribution
TMEM106A Expression in NALM6 Cells: 3.68
