TMIE
Gene Information
- Official Symbol: TMIE
- Official Name: transmembrane inner ear
- Aliases and Previous Symbols: N/A
- Entrez ID: 259236
- UniProt: Q8NEW7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a transmembrane inner ear protein. Studies in mouse suggest that this gene is required for normal postnatal maturation of sensory hair cells in the cochlea, including correct development of stereocilia bundles. This gene is one of multiple genes responsible for recessive non-syndromic deafness (DFNB), also known as autosomal recessive nonsyndromic hearing loss (ARNSHL), the most common form of congenitally acquired inherited hearing impairment. [provided by RefSeq, Mar 2009].
- UniProt Summary: Unknown. The protein may play some role in a cellular membrane location. May reside within an internal membrane compartment and function in pathways such as those involved in protein and/or vesicle trafficking. Alternatively, the mature protein may be localized in the plasma membrane and serve as a site of interaction for other molecules through its highly charged C-terminal domain.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 13328
- Expression level (log2 read counts): 3.33
TMIE Expression in NALM6 Cells: 3.33
