TMSB4X
Gene Information
- Official Symbol: TMSB4X
- Official Name: thymosin beta 4 X-linked
- Aliases and Previous Symbols: N/A
- Entrez ID: 7114
- UniProt: P62328
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| Thymosin |
GO Terms
| positive regulation of proton-transporting ATP synthase activity, rotational mechanism |
| regulation of proton-transporting ATP synthase activity, rotational mechanism |
| negative regulation of interleukin-8 secretion |
| negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding |
| cytoplasmic sequestering of NF-kappaB |
| sequestering of actin monomers |
| positive regulation of ATP biosynthetic process |
| regulation of RNA polymerase II regulatory region sequence-specific DNA binding |
| positive regulation of endothelial cell chemotaxis |
| cytoplasmic sequestering of transcription factor |
| regulation of ATP biosynthetic process |
| negative regulation of interleukin-8 production |
| negative regulation of transcription regulatory region DNA binding |
| regulation of endothelial cell chemotaxis |
| regulation of proton transport |
| negative regulation of NIK/NF-kappaB signaling |
| positive regulation of nucleotide biosynthetic process |
| positive regulation of purine nucleotide biosynthetic process |
| cytoplasmic sequestering of protein |
| regulation of interleukin-8 secretion |
| actin monomer binding |
| regulation of purine nucleotide biosynthetic process |
| regulation of nucleotide biosynthetic process |
| positive regulation of ATP metabolic process |
| positive regulation of nucleotide metabolic process |
| positive regulation of purine nucleotide metabolic process |
| regulation of transcription regulatory region DNA binding |
| negative regulation of actin filament polymerization |
| positive regulation of blood vessel endothelial cell migration |
| negative regulation of DNA binding |
| negative regulation of protein polymerization |
| platelet alpha granule lumen |
| negative regulation of cytokine secretion |
| regulation of interleukin-8 production |
| maintenance of protein location in cell |
| negative regulation of NF-kappaB transcription factor activity |
| regulation of blood vessel endothelial cell migration |
| maintenance of location in cell |
| positive regulation of endothelial cell migration |
| positive regulation of ion transmembrane transporter activity |
| maintenance of protein location |
| regulation of NIK/NF-kappaB signaling |
| positive regulation of transporter activity |
| regulation of purine nucleotide metabolic process |
| regulation of nucleotide metabolic process |
| tumor necrosis factor-mediated signaling pathway |
| regulation of ATP metabolic process |
| regulation of DNA binding |
| platelet degranulation |
| negative regulation of supramolecular fiber organization |
| negative regulation of protein complex assembly |
| negative regulation of protein secretion |
| positive regulation of chemotaxis |
| positive regulation of small molecule metabolic process |
| negative regulation of cytoskeleton organization |
| negative regulation of peptide secretion |
| positive regulation of epithelial cell migration |
| positive regulation of cation transmembrane transport |
| positive regulation of ion transmembrane transport |
| regulation of endothelial cell migration |
| negative regulation of DNA-binding transcription factor activity |
| maintenance of location |
| regulation of actin filament polymerization |
| negative regulation of binding |
| negative regulation of protein transport |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| negative regulation of establishment of protein localization |
| positive regulation of transmembrane transport |
| negative regulation of secretion by cell |
| regulation of cytokine secretion |
| regulation of chemotaxis |
| regulation of epithelial cell migration |
| regulation of protein polymerization |
| negative regulation of secretion |
| actin filament organization |
| cellular response to tumor necrosis factor |
| regulation of ion transmembrane transporter activity |
| regulation of actin filament organization |
| response to tumor necrosis factor |
| regulation of transmembrane transporter activity |
| negative regulation of cytokine production |
| positive regulation of ion transport |
| regulation of transporter activity |
| regulation of cation transmembrane transport |
| regulation of inflammatory response |
| regulation of actin cytoskeleton organization |
| enzyme binding |
| regulation of supramolecular fiber organization |
| cytoskeleton |
| negative regulation of organelle organization |
| regulation of binding |
| regulation of cellular component size |
| regulation of actin filament-based process |
| regulation of small molecule metabolic process |
| regulation of DNA-binding transcription factor activity |
| regulation of protein complex assembly |
| supramolecular fiber organization |
| regulation of protein secretion |
| regulation of ion transmembrane transport |
| negative regulation of transport |
| actin cytoskeleton organization |
| regulation of peptide secretion |
| positive regulation of cell migration |
| negative regulation of intracellular signal transduction |
| regulation of anatomical structure size |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| regulation of cytoskeleton organization |
| positive regulation of locomotion |
| regulation of transmembrane transport |
| actin filament-based process |
| positive regulation of response to external stimulus |
| cytokine-mediated signaling pathway |
| regulation of cytokine production |
| regulation of ion transport |
| regulated exocytosis |
| negative regulation of cellular component organization |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of defense response |
| exocytosis |
| regulation of secretion |
| regulation of cell migration |
| regulation of cell motility |
| regulation of cellular component biogenesis |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| secretion by cell |
| cellular response to cytokine stimulus |
| regulation of protein localization |
| export from cell |
| regulation of response to external stimulus |
| response to cytokine |
| cytoskeleton organization |
| secretion |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| negative regulation of multicellular organismal process |
| negative regulation of signal transduction |
| regulation of organelle organization |
| negative regulation of cell communication |
| negative regulation of signaling |
| RNA binding |
| regulation of response to stress |
| cellular protein localization |
| cellular macromolecule localization |
| negative regulation of response to stimulus |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| extracellular region |
| vesicle-mediated transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/694
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/26 |
| bone | 0/26 |
| breast | 0/30 |
| central nervous system | 0/49 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/11 |
| fibroblast | 0/1 |
| gastric | 0/14 |
| kidney | 0/18 |
| liver | 0/19 |
| lung | 0/72 |
| lymphocyte | 0/16 |
| ovary | 0/25 |
| pancreas | 0/22 |
| peripheral nervous system | 0/15 |
| plasma cell | 0/12 |
| prostate | 0/1 |
| skin | 0/20 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/28 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16189
- Expression level (log2 read counts): 9.79
Expression Distribution
TMSB4X Expression in NALM6 Cells: 9.79
