Pfam Domains GO Terms
| TNF |
| CD8-positive, alpha-beta T cell differentiation |
| CD8-positive, alpha-beta T cell activation |
| tumor necrosis factor receptor binding |
| alpha-beta T cell differentiation |
| alpha-beta T cell activation |
| defense response to Gram-positive bacterium |
| tumor necrosis factor-mediated signaling pathway |
| T cell differentiation |
| regulation of T cell proliferation |
| cytokine activity |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| regulation of leukocyte proliferation |
| T cell activation |
| lymphocyte differentiation |
| cellular response to tumor necrosis factor |
| response to tumor necrosis factor |
| regulation of T cell activation |
| defense response to bacterium |
| leukocyte differentiation |
| signaling receptor binding |
| lymphocyte activation |
| regulation of lymphocyte activation |
| hemopoiesis |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| regulation of cell activation |
| immune system development |
| cytokine-mediated signaling pathway |
| response to bacterium |
| leukocyte activation |
| defense response to other organism |
| cellular response to cytokine stimulus |
| cell activation |
| response to cytokine |
| cell-cell signaling |
| positive regulation of transcription by RNA polymerase II |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| integral component of plasma membrane |
| positive regulation of transcription, DNA-templated |
| extracellular space |
| regulation of cell population proliferation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of immune system process |
| positive regulation of RNA metabolic process |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| Disulfiram 4.3μM R06 exp281 | 1.74 |
| FK-506 30μM R07 exp359 | 1.81 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution