TNRC6A
Gene Information
- Official Symbol: TNRC6A
- Official Name: trinucleotide repeat containing adaptor 6A
- Aliases and Previous Symbols: N/A
- Entrez ID: 27327
- UniProt: Q8NDV7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Ago hook |
GO Terms
| positive regulation of nuclear-transcribed mRNA poly(A) tail shortening |
| regulation of translation, ncRNA-mediated |
| negative regulation of translation, ncRNA-mediated |
| miRNA mediated inhibition of translation |
| regulation of nuclear-transcribed mRNA poly(A) tail shortening |
| RISC complex |
| positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| Wnt signaling pathway, calcium modulating pathway |
| gene silencing by miRNA |
| positive regulation of mRNA catabolic process |
| regulation of megakaryocyte differentiation |
| posttranscriptional gene silencing by RNA |
| posttranscriptional gene silencing |
| positive regulation of mRNA metabolic process |
| P-body |
| gene silencing by RNA |
| regulation of gene silencing by miRNA |
| regulation of posttranscriptional gene silencing |
| regulation of gene silencing by RNA |
| regulation of gene silencing |
| negative regulation of translation |
| non-canonical Wnt signaling pathway |
| negative regulation of cellular amide metabolic process |
| cellular response to starvation |
| gene silencing |
| response to starvation |
| regulation of mRNA catabolic process |
| regulation of myeloid cell differentiation |
| cellular response to nutrient levels |
| regulation of gene expression, epigenetic |
| cellular response to extracellular stimulus |
| regulation of mRNA metabolic process |
| cellular response to external stimulus |
| regulation of translation |
| cell-cell signaling by wnt |
| Wnt signaling pathway |
| positive regulation of cellular catabolic process |
| regulation of cellular amide metabolic process |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| positive regulation of catabolic process |
| regulation of hemopoiesis |
| response to nutrient levels |
| posttranscriptional regulation of gene expression |
| response to extracellular stimulus |
| intracellular membrane-bounded organelle |
| regulation of cellular catabolic process |
| Golgi apparatus |
| regulation of catabolic process |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| cell-cell signaling |
| negative regulation of cellular macromolecule biosynthetic process |
| RNA binding |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| regulation of immune system process |
| cellular response to stress |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Metformin 40μM R03 exp132 | -1.99 |
| Pomalidomide 20μM R07 exp391 | -1.84 |
| Vinorelbine 0.001μM R05 exp249 | -1.8 |
| Doxorubicin 0.02μM R08 exp478 | 1.71 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3914
- Expression level (log2 read counts): 7.35
Expression Distribution
TNRC6A Expression in NALM6 Cells: 7.35
