TREM1
Gene Information
- Official Symbol: TREM1
- Official Name: triggering receptor expressed on myeloid cells 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 54210
- UniProt: Q9NP99
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011].
- UniProt Summary: Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. {ECO:0000269|PubMed:10799849, ECO:0000269|PubMed:11323674}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 11074
- Expression level (log2 read counts): -2.43
TREM1 Expression in NALM6 Cells: -2.43
