TRIM46
Gene Information
- Official Symbol: TRIM46
- Official Name: tripartite motif containing 46
- Aliases and Previous Symbols: N/A
- Entrez ID: 80128
- UniProt: Q7Z4K8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| zf-B box |
| zf-C3HC4 |
GO Terms
| regulation of dense core granule transport |
| regulation of anterograde dense core granule transport |
| positive regulation of anterograde dense core granule transport |
| positive regulation of dense core granule transport |
| positive regulation of vesicle transport along microtubule |
| proximal neuron projection |
| regulation of vesicle transport along microtubule |
| main axon |
| protein localization to axon |
| regulation of organelle transport along microtubule |
| positive regulation of cytoplasmic transport |
| synaptic vesicle transport along microtubule |
| synaptic vesicle cytoskeletal transport |
| anterograde synaptic vesicle transport |
| axon initial segment |
| regulation of cytoplasmic transport |
| regulation of microtubule-based movement |
| synaptic vesicle transport |
| synaptic vesicle localization |
| negative regulation of axon extension |
| vesicle transport along microtubule |
| anterograde axonal transport |
| vesicle cytoskeletal trafficking |
| axonal transport |
| axon cytoplasm |
| axo-dendritic transport |
| negative regulation of axonogenesis |
| organelle transport along microtubule |
| microtubule bundle formation |
| regulation of axon extension |
| negative regulation of cell morphogenesis involved in differentiation |
| negative regulation of developmental growth |
| regulation of extent of cell growth |
| neuron migration |
| negative regulation of neuron projection development |
| transport along microtubule |
| establishment of vesicle localization |
| cytoskeleton-dependent intracellular transport |
| regulation of cell size |
| negative regulation of cell projection organization |
| microtubule-based transport |
| negative regulation of cell growth |
| vesicle localization |
| regulation of axonogenesis |
| positive regulation of intracellular transport |
| regulation of microtubule-based process |
| negative regulation of neuron differentiation |
| negative regulation of growth |
| microtubule-based movement |
| negative regulation of neurogenesis |
| regulation of cell morphogenesis involved in differentiation |
| negative regulation of nervous system development |
| regulation of developmental growth |
| negative regulation of cell development |
| regulation of intracellular transport |
| establishment of organelle localization |
| cytoskeleton |
| axonogenesis |
| regulation of cellular component size |
| axon development |
| regulation of cell growth |
| cell morphogenesis involved in neuron differentiation |
| microtubule cytoskeleton organization |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| regulation of cell morphogenesis |
| regulation of neuron projection development |
| regulation of anatomical structure size |
| cell part morphogenesis |
| positive regulation of cellular component movement |
| regulation of cellular protein localization |
| cell morphogenesis involved in differentiation |
| organelle localization |
| regulation of neuron differentiation |
| neuron projection development |
| microtubule-based process |
| regulation of growth |
| regulation of plasma membrane bounded cell projection organization |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| cell morphogenesis |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| zinc ion binding |
| regulation of cellular localization |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| cell migration |
| positive regulation of transport |
| regulation of cellular component movement |
| neuron differentiation |
| regulation of protein localization |
| regulation of anatomical structure morphogenesis |
| localization of cell |
| cell motility |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| negative regulation of multicellular organismal process |
| locomotion |
| intracellular transport |
| generation of neurons |
| movement of cell or subcellular component |
| neurogenesis |
| cell development |
| regulation of cell differentiation |
| establishment of localization in cell |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Tozasertib 0.1μM R07 exp414 | -2.09 |
| VE-822 0.04μM R06 exp300 | -1.75 |
| HMS-I2 1μM R06 exp286 | -1.73 |
| QNZ 0.01μM R05 exp241 | 2.02 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6184
- Expression level (log2 read counts): 1.09
Expression Distribution
TRIM46 Expression in NALM6 Cells: 1.09
