TRIM6
Gene Information
- Official Symbol: TRIM6
- Official Name: tripartite motif containing 6
- Aliases and Previous Symbols: N/A
- Entrez ID: 117854
- UniProt: Q9C030
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: E3 ubiquitin-protein ligase which ubiquitinates MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (By similarity). Involved in the synthesis of unanchored K48-linked polyubiquitin chains which interact with and activate the serine/threonine kinase IKBKE, leading to phosphorylation of STAT1 and stimulation of an antiviral response (PubMed:24882218). {ECO:0000250|UniProtKB:Q8BGE7, ECO:0000269|PubMed:24882218}.
Pfam Domains GO Terms
Pfam Domains
| zf-C3HC4 |
| zf-B box |
| SPRY |
GO Terms
| free ubiquitin chain polymerization |
| positive regulation of cytokine secretion involved in immune response |
| ubiquitin recycling |
| positive regulation of type I interferon-mediated signaling pathway |
| regulation of cytokine secretion involved in immune response |
| cellular response to interferon-beta |
| negative regulation of stem cell differentiation |
| positive regulation of transcription regulatory region DNA binding |
| positive regulation of defense response to virus by host |
| protein tyrosine kinase binding |
| response to interferon-beta |
| positive regulation of peptidyl-threonine phosphorylation |
| cellular response to virus |
| regulation of type I interferon-mediated signaling pathway |
| regulation of defense response to virus by host |
| regulation of peptidyl-threonine phosphorylation |
| positive regulation of cytokine-mediated signaling pathway |
| regulation of transcription regulatory region DNA binding |
| positive regulation of cytokine production involved in immune response |
| protein trimerization |
| positive regulation of DNA binding |
| positive regulation of response to cytokine stimulus |
| negative regulation of viral genome replication |
| regulation of defense response to virus |
| protein binding, bridging |
| negative regulation of viral life cycle |
| regulation of cytokine production involved in immune response |
| protein polymerization |
| regulation of viral genome replication |
| positive regulation of production of molecular mediator of immune response |
| negative regulation of viral process |
| positive regulation of peptidyl-serine phosphorylation |
| regulation of NIK/NF-kappaB signaling |
| regulation of stem cell differentiation |
| regulation of DNA binding |
| regulation of peptidyl-serine phosphorylation |
| positive regulation of cytokine secretion |
| regulation of production of molecular mediator of immune response |
| regulation of viral life cycle |
| regulation of cytokine-mediated signaling pathway |
| regulation of response to cytokine stimulus |
| positive regulation of binding |
| regulation of cytokine secretion |
| regulation of viral process |
| negative regulation of multi-organism process |
| positive regulation of immune effector process |
| regulation of symbiosis, encompassing mutualism through parasitism |
| ubiquitin protein ligase activity |
| positive regulation of protein secretion |
| response to virus |
| positive regulation of peptide secretion |
| protein polyubiquitination |
| response to lipopolysaccharide |
| response to molecule of bacterial origin |
| transcription factor binding |
| positive regulation of innate immune response |
| positive regulation of response to biotic stimulus |
| regulation of binding |
| positive regulation of secretion by cell |
| positive regulation of protein transport |
| positive regulation of secretion |
| positive regulation of cytokine production |
| regulation of innate immune response |
| positive regulation of establishment of protein localization |
| protein kinase binding |
| regulation of protein secretion |
| regulation of immune effector process |
| positive regulation of defense response |
| regulation of peptide secretion |
| positive regulation of multi-organism process |
| protein complex oligomerization |
| regulation of response to biotic stimulus |
| positive regulation of response to external stimulus |
| protein ubiquitination |
| response to bacterium |
| regulation of cytokine production |
| viral process |
| regulation of protein transport |
| negative regulation of cell differentiation |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of defense response |
| protein modification by small protein conjugation |
| regulation of multi-organism process |
| symbiotic process |
| regulation of secretion |
| interspecies interaction between organisms |
| zinc ion binding |
| cellular protein-containing complex assembly |
| response to lipid |
| positive regulation of immune response |
| cellular homeostasis |
| negative regulation of developmental process |
| protein modification by small protein conjugation or removal |
| positive regulation of transport |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| regulation of protein localization |
| positive regulation of phosphorylation |
| regulation of response to external stimulus |
| response to cytokine |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| negative regulation of transcription, DNA-templated |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| homeostatic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| regulation of transport |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Chloramphenicol 2μM R00 exp12 | 1.74 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9174
- Expression level (log2 read counts): 3.74
Expression Distribution
TRIM6 Expression in NALM6 Cells: 3.74
