Entrez Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A
Pfam DomainsGO Terms
Pfam Domains
Tetraspannin
GO Terms
negative regulation of blood coagulation
negative regulation of hemostasis
negative regulation of coagulation
negative regulation of wound healing
regulation of blood coagulation
regulation of hemostasis
regulation of coagulation
negative regulation of response to wounding
integrin binding
regulation of wound healing
regulation of response to wounding
negative regulation of response to external stimulus
regulation of body fluid levels
spermatogenesis
male gamete generation
cell surface
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
multi-organism reproductive process
regulation of response to external stimulus
negative regulation of multicellular organismal process
integral component of plasma membrane
reproductive process
reproduction
regulation of response to stress
negative regulation of response to stimulus
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)