TUSC2
Gene Information
- Official Symbol: TUSC2
- Official Name: tumor suppressor 2, mitochondrial calcium regulator
- Aliases and Previous Symbols: N/A
- Entrez ID: 11334
- UniProt: O75896
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| interleukin-15 production |
| response to defense-related host reactive oxygen species production |
| response to defense-related reactive oxygen species production by other organism involved in symbiotic interaction |
| chemokine (C-C motif) ligand 5 production |
| neutrophil mediated killing of gram-negative bacterium |
| neutrophil mediated killing of bacterium |
| neutrophil mediated killing of symbiont cell |
| response to immune response of other organism involved in symbiotic interaction |
| response to host immune response |
| neutrophil mediated cytotoxicity |
| response to host defenses |
| response to defenses of other organism involved in symbiotic interaction |
| response to host |
| natural killer cell differentiation |
| killing by host of symbiont cells |
| chemokine production |
| disruption by host of symbiont cells |
| killing of cells in other organism involved in symbiotic interaction |
| disruption of cells of other organism involved in symbiotic interaction |
| negative regulation of interleukin-17 production |
| regulation of interleukin-17 production |
| positive regulation of interleukin-10 production |
| leukocyte mediated cytotoxicity |
| killing of cells of other organism |
| disruption of cells of other organism |
| regulation of interleukin-10 production |
| natural killer cell activation |
| regulation of mitochondrial membrane potential |
| modification by host of symbiont morphology or physiology |
| interaction with symbiont |
| defense response to Gram-negative bacterium |
| cell killing |
| modification of morphology or physiology of other organism involved in symbiotic interaction |
| cytokine production |
| modification of morphology or physiology of other organism |
| interaction with host |
| cell maturation |
| regulation of reactive oxygen species metabolic process |
| lymphocyte differentiation |
| developmental maturation |
| negative regulation of cytokine production |
| phagocytosis |
| defense response to bacterium |
| leukocyte differentiation |
| lymphocyte activation |
| regulation of membrane potential |
| positive regulation of cytokine production |
| neutrophil mediated immunity |
| inflammatory response |
| myeloid leukocyte mediated immunity |
| hemopoiesis |
| hematopoietic or lymphoid organ development |
| immune system development |
| response to bacterium |
| regulation of cytokine production |
| leukocyte mediated immunity |
| symbiotic process |
| interspecies interaction between organisms |
| leukocyte activation |
| defense response to other organism |
| cell activation |
| immune effector process |
| negative regulation of multicellular organismal process |
| mitochondrion |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| cell cycle |
| cell development |
| positive regulation of multicellular organismal process |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Bortezomib 0.005μM R00 exp6 | -1.73 |
| MS023 2μM R03 exp134 | -1.7 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18075
- Expression level (log2 read counts): 4.84
Expression Distribution
TUSC2 Expression in NALM6 Cells: 4.84
